Abstract We have established a facile and versatile synthesis for the construction of isothiocyanates from their respective amines in the presence of an eco-friendly, inexpensive, easily available Iron catalyst under mild conditions. This reaction provides the target products through the formation of thiocarbamate salt as an intermediate. Both aromatic amines and aliphatic amines provided the respective target products in moderate to high yield under optimized reaction conditions. However, electron withdrawing substituents were difficult to give target product at room temperature, whereas, they obtained final products in good yield at moderate temperature. In addition, mechanistic studies were revealed that the synthetic route involved iron based subsequent reactions of addition and removal of sulfur. Graphical Abstract

中文翻译：

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铁促进的一锅法：异硫氰酸酯的合成

摘要 我们已经建立了一种简便且通用的合成方法，用于在温和条件下，在环保、廉价、易得的铁催化剂存在下，由各自的胺构建异硫氰酸酯。该反应通过形成硫代氨基甲酸盐作为中间体来提供目标产物。在优化的反应条件下，芳香胺和脂肪胺均以中等至高产率提供各自的目标产物。然而，吸电子取代基在室温下难以得到目标产物，而在中等温度下它们以良好的收率获得最终产物。此外，机理研究表明，合成路线涉及基于铁的后续加硫和脱硫反应。图形概要