ABSTRACT An ozone generation system using V-UV excimer lamps (172nm) and an optical measurement system based on the Beer–Lambert law were developed for an efficient low-temperature (15 °C-30 °C) sterilization of medical devices. Ozone concentrations between 100 and 1ʹ000 ppm (0.2–2 g/Nm3) were generated and the impact of several variables on the sterilization outcome were studied. The survivor curves of the sterilization process were obtained for biological indicators (BIs) inoculated with Geobacillus stearothermophilus spores. A lag phase was observed before the start of the actual sterilization which followed first-order log-linear kinetics. The results demonstrated the feasibility to sterilize medical devices with ozone at ambient temperatures, reducing the consumption of resources and the cost of sterilization.

中文翻译：

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实现医疗器械的高效低温臭氧气体灭菌

摘要开发了使用 V-UV 准分子灯 (172nm) 的臭氧生成系统和基于比尔-朗伯定律的光学测量系统，用于医疗器械的高效低温 (15°C-30°C) 灭菌。臭氧浓度在 100 到 1ʹ000 ppm (0.2–2 g/Nm3) 之间，并研究了几个变量对灭菌结果的影响。获得了接种嗜热脂肪地芽孢杆菌孢子的生物指示剂 (BI) 的灭菌过程的存活曲线。在遵循一阶对数线性动力学的实际灭菌开始之前观察到滞后期。结果证明了在环境温度下用臭氧对医疗器械进行消毒的可行性，从而减少了资源消耗和消毒成本。