Although neglect is known to be a multimodal deficit, current interventions often address the visual modality only. Experimental studies, however, found that neglect patients can partially overcome their spatial inattention temporarily when being exposed to auditory cues that move towards the neglected side of space. Two pilot studies investigated the impact of dynamic auditory cueing on egocentric neglect severity in a clinical-therapeutic setting. In both studies, the patient groups received 15 sessions of intervention. Study 1, designed as double-blinded trial with a historical control group, targeted severely impaired early-acute patients who listened to music or audio books which were presented as moving dynamically from right to left. Results showed a reduction in egocentric neglect severity that persisted after therapy termination in the intervention but not in the historical control group. In study 2, based on the comparison with reported effect sizes of previous studies, dynamic meaningful auditory cues and optokinetic stimulation were combined in a computer-based training. Both studies found a significant reduction of neglect severity. Results provide evidence for the reduction of egocentric neglect severity after repetitive auditory cueing therapy in both severely and moderately impaired patients. Our promising findings should be verified thoroughly in randomized-controlled trials.

中文翻译：

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听觉线索可以改善视觉空间忽视吗？两项试点研究的结果

尽管众所周知，忽视是一种多模式缺陷，但当前的干预措施通常只针对视觉模式。然而，实验研究发现，当暴露于朝向空间被忽视侧移动的听觉线索时，被忽视的患者可以暂时克服他们的空间注意力不集中。两项试点研究调查了动态听觉提示对临床治疗环境中以自我为中心的忽视严重程度的影响。在这两项研究中，患者组接受了 15 次干预。研究 1 设计为具有历史对照组的双盲试验，针对严重受损的早期急性患者，他们听音乐或有声读物，这些音乐或有声读物呈现为从右向左动态移动。结果显示，在干预治疗终止后，以自我为中心的忽视严重程度有所降低，但在历史对照组中则不然。在研究 2 中，基于与先前研究报告的效应大小的比较，动态有意义的听觉线索和视动刺激结合在基于计算机的培训中。两项研究都发现忽视严重程度显着降低。结果为重度和中度受损患者在重复听觉提示治疗后减少以自我为中心的忽视严重程度提供了证据。我们有希望的发现应该在随机对照试验中得到彻底验证。在基于计算机的培训中结合了动态有意义的听觉线索和视动刺激。两项研究都发现忽视严重程度显着降低。结果为重度和中度受损患者在重复听觉提示治疗后减少以自我为中心的忽视严重程度提供了证据。我们有希望的发现应该在随机对照试验中得到彻底验证。动态有意义的听觉线索和视动刺激结合在基于计算机的培训中。两项研究都发现忽视严重程度显着降低。结果为重度和中度受损患者在重复听觉提示治疗后减少以自我为中心的忽视严重程度提供了证据。我们有希望的发现应该在随机对照试验中得到彻底验证。