Abstract

Through feeding 1,2-dimethylindole, two new bisindoles, chaetoindolone E and F (1 and 2) and five known indole derivatives (3–7) were isolated from the cultures of an endophytic fungus Chaetomium sp. The structures of these compounds were elucidated based on HR-MS, NMR and single-crystal X-ray crystallography. Compounds 1 and 2 were undescribed before, compounds 3–7 were first reported from natural sources, and NMR spectrums of compounds 4 and 5 were first reported. The cytotoxity of the bisindole compounds (1–3) was also tested.

中文翻译：

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由内生真菌毛壳菌产生吲哚衍生物。通过喂食1,2-二甲基吲哚

摘要

通过进料1,2-二甲基吲哚，两个新的双吲哚，chaetoindolone E和F（1和2）和5个已知的吲哚衍生物（3 - 7）从一个内生真菌的培养物中分离毛壳菌。基于HR-MS、NMR和单晶X射线晶体学阐明了这些化合物的结构。化合物1和2进行了前未描述的，化合物3 - 7首先从天然来源的报道，和化合物的NMR谱4和5为首次报道。双吲哚化合物的细胞毒性 ( 1 – 3) 也进行了测试。