Abstract

A new alkylresorcinol, myrothecol A (1), along with two known ones (2 and 3), were isolated from a fungal strain Myrothecium sp. GY170016. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by electronic circular dichroism experiment. This is the first case of the presence of alkylresorcinols in genus Myrothecium. All the isolates were evaluated for their cytotoxic activities against human cancer cell line MCF-7 with IC₅₀ values of 16.7, 13.2, 21.3 μM, respectively.

中文翻译：

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Myrothecol A，一种来自 Myrothecium sp. 的具有细胞毒性的新型烷基间苯二酚。

摘要

从真菌菌株Myrothecium sp.中分离出一种新的烷基间苯二酚，myrothecol A ( 1 )，以及两个已知的烷基间苯二酚（2和3）。GY170016。通过广泛的光谱分析阐明了它们的结构。的绝对构型1由电子圆二色性实验确定。这是烷基间苯二酚的属中存在的第一种情况下漆斑。评估了所有分离株对人癌细胞系 MCF-7 的细胞毒活性，IC ₅₀值 分别为16.7、13.2、21.3 μM。