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Myrothecol A, a new alkylresorcinol with cytotoxicity from Myrothecium sp.
Natural Product Research ( IF 2.158 ) Pub Date : 2020-05-07 , DOI: 10.1080/14786419.2020.1762191
Zhen-Hua Li,Hui-Yuan Yang,Wen-Ting Zhu,Dong-Dong Jing,Shi-Neng Li,Peng-Ke Yan

A new alkylresorcinol, myrothecol A (1), along with two known ones (2 and 3), were isolated from a fungal strain Myrothecium sp. GY170016. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by electronic circular dichroism experiment. This is the first case of the presence of alkylresorcinols in genus Myrothecium. All the isolates were evaluated for their cytotoxic activities against human cancer cell line MCF-7 with IC50 values of 16.7, 13.2, 21.3 μM, respectively.
更新日期:2020-05-07

 

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