Abstract

Five new lignans, euphorhirtins A–D (1–4), 5-methoxyvirgatusin (5), three artefacts, 7S-ethoxyisolintetralin (6), 7R-ethoxyisolintetralin (7), and 7R-ethoxy-3-methoxyisolintetralin (8), together with 13 known ones (9–21) were isolated from the medicinal plant Euphorbia hirta L. The structures of the compounds were elucidated by means of extensive spectroscopic analysis, including 1D and 2D NMR and HR-ESI-MS experiments. The absolute configurations of compound 1 was determined by ECD calculation. The isolates were evaluated for their inhibitory effects against the proliferation of the cancer cell lines (Hep G2, A549, and DU145) and compounds 14 and 18 showed inhibitory activity against the Hep G2 cells with IC₅₀ values 7.2 ± 0.17 and 8.5 ± 0.36 μM.

摘要

五种新的木脂素，大戟素 A-D ( 1 - 4 )，5-methoxyvirgatusin ( 5 )，三种人工制品，7 S -ethoxyisolintetralin ( 6 )，7 R -ethoxyisolintetralin ( 7 )，和 7 R -ethoxy-3-methoxyisolintetralin (从药用植物Euphorbia hirta L中分离出 13 个已知化合物 (9-21) 。化合物的结构通过广泛的光谱分析进行了阐明，包括 1D 和 2D NMR 和 HR-ESI-MS 实验。化合物1的绝对构型由 ECD 计算确定。评估了分离物对癌细胞系（Hep G2、A549 和 DU145）增殖的抑制作用，化合物14和18对 Hep G2 细胞显示出抑制活性，IC ₅₀值为 7.2 ± 0.17 和 8.5 ± 0.36  μ M。