Abstract

Objective

We assessed the quality of life (QoL) and pregnancy outcomes of in vitro fertilization (IVF) treatment among infertile women with endometriosis, as compared to infertile women without endometriosis.

Study design

Eighty-one (81) endometriosis women (with 142 embryo transfer [ET] cycles) and 605 non-endometriosis women (with 1063 ET cycles) were included. QoL was measured by FertiQoL at the date before ET. Pregnancy outcomes included biochemical pregnancy, ongoing pregnancy and live birth. Generalized estimating equation analyses were performed to assess the association between QoL and IVF pregnancy.

Results

Endometriosis-affected women had significantly lower QoL, as indicated by mind/body, treatment environment and total treatment scores, and total scores of FertiQoL (p < .05), compared to those without endometriosis. Among non-endometriosis women, QoL scores were significantly associated with successful IVF pregnancy; with one unit increase in QoL scores as measured by emotional domain of FertiQoL, the probabilities of ongoing pregnancy and live birth significantly increased by 2.5% and 2.8%, respectively (p < .05). This association was also observed among endometriosis women but it did not reach statistical significance.

Conclusions

Lower QoL among women with endometriosis versus non-endometriosis during IVF treatment highlights the importance of developing strategies to improve their QoL, which may enhance following pregnancy rates in this population.

中文翻译：

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接受IVF治疗的子宫内膜异位症不孕妇女的生活质量及其妊娠结局

抽象的

客观的

与没有子宫内膜异位症的不育女性相比，我们评估了患有子宫内膜异位症的不育女性的生活质量（QoL）和体外受精（IVF）治疗的妊娠结局。

学习规划

包括八十一（81）位子宫内膜异位症妇女（具有142个胚胎移植[ET]周期）和605名非子宫内膜异位症妇女（具有1063 ET周期）。生活质量是在东部标准时间之前通过FertiQoL测量的。妊娠结局包括生化妊娠，持续妊娠和活产。进行了广义估计方程分析，以评估QoL和IVF妊娠之间的关联。

结果

与没有子宫内膜异位症的女性相比，受子宫内膜异位症影响的女性的QoL显着降低，如心理/身体，治疗环境和总治疗分数以及FertiQoL的总分数所表明（p  <.05）。在非子宫内膜异位症女性中，QoL评分与成功的IVF怀孕显着相关；通过FertiQoL的情感领域来衡量，QoL分数增加了一个单位，则正在进行妊娠和活产的概率分别显着增加了2.5％和2.8％（p  <.05）。在子宫内膜异位症妇女中也观察到这种关联，但未达到统计学意义。

结论

在进行IVF治疗期间，子宫内膜异位症患者和非子宫内膜异位症女性的较低QoL突显了制定改善其QoL的策略的重要性，这可能会增加该人群的妊娠率。