Abstract A series of chiral alternating copolymers based on glycyl-glycine attached styrenic monomer (VG) and alanyl-alanine tethered maleimide (MA) are synthesized through reversible addition-fragmentation chain transfer (RAFT) polymerization. The alternating sequential arrangement of the two monomers along the synthetic copolymer chain is systematically established through 1H and 13C NMR spectroscopic investigation. The thermal as well as chiroptical characteristics of the copolymers are also studied. Interestingly, the copolymers show unusual luminescence characteristics in different organic solvents under UV light irradiation, whereas in the solid state they emit blue, green and red fluorescence as witnessed from the corresponding fluorescence microscopy micrographs. Furthermore, after successful Boc group removal, the deprotected copolymers show pH-dependent solubility variation in aqueous solution with an almost invariant transition pH with respect to varying chain lengths of the polymers. Thus, the strategy reported herein offers a notable direction to fabricate various dipeptide-based sequence-controlled polymers with promising applications.

中文翻译：

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具有甘氨酰-甘氨酸和丙氨酰-丙氨酸侧链侧链的交替共聚物：合成、表征和溶液性质

摘要 通过可逆加成-断裂链转移（RAFT）聚合反应合成了一系列基于甘氨酰-甘氨酸连接的苯乙烯单体（VG）和丙氨酰-丙氨酸系链马来酰亚胺（MA）的手性交替共聚物。通过 1H 和 13C NMR 光谱研究系统地建立了两种单体沿合成共聚物链的交替顺序排列。还研究了共聚物的热特性和手性特性。有趣的是，在紫外光照射下，共聚物在不同有机溶剂中显示出不寻常的发光特性，而在固态下，它们发出蓝色、绿色和红色荧光，如相应的荧光显微镜显微照片所见。此外，在成功移除 Boc 组后，脱保护的共聚物在水溶液中显示出依赖于 pH 值的溶解度变化，并且相对于不同的聚合物链长，其转变 pH 值几乎不变。因此，本文报道的策略为制造各种具有前景的基于二肽的序列控制聚合物提供了一个显着的方向。