The technique of thermally induced phase separation (TIPS) is favorable for the fabrication of a porous scaffold due to a number of advantages. In this work the poly(L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) terpolymer was synthesized by melt copolymerization and porous scaffolds thereof from its solution in 1,4-dioxane were fabricated by using the TIPS method. The effects of fabrication parameters, including polymer concentration and freezing temperature, on the morphology, pore size and mechanical properties were studied. The results showed that the average pore size of the PLLGC porous scaffold increased with a decrease in PLLGC concentration and the pore size resulting from freezing at 4 °C (about 20–100 μm) was significantly larger than for other samples (20–50 μm) frozen at lower temperatures. The porosity of the scaffolds decreased with increasing PLLGC concentration or decreasing freezing temperature. On the other hand, the compressive strength of the scaffolds increased with the increase of PLLGC concentration or the decrease of freezing temperature, as would be expected. The present results can be applied in design to control the processing parameters of TIPS for a scaffold with desired pore morphology.

由于许多优点，热诱导相分离（TIPS）技术对于多孔支架的制造是有利的。在这项工作中，聚（L-丙交酯-乙交酯-共-ε-己内酯）（PLLGC）三元共聚物通过熔融共聚合成，并使用TIPS方法由其在1,4-二恶烷中的溶液制成多孔支架。研究了包括聚合物浓度和凝固温度在内的制备参数对形貌，孔径和力学性能的影响。结果表明，PLLGC多孔支架的平均孔径随PLLGC浓度的降低而增加，并且在4°C下冻结（约20–100μm）产生的孔径明显大于其他样品（20–50μm） ）在较低的温度下冷冻。支架的孔隙率随PLLGC浓度的增加或冷冻温度的降低而降低。另一方面，如预期的那样，支架的抗压强度随着PLLGC浓度的增加或冷冻温度的降低而增加。本结果可用于设计以控制具有期望的孔形态的支架的TIPS的加工参数。