Abstract A rapid and reliable method based on supercritical fluid chromatography (SFC) technology was established for the analysis of 14 ultraviolet (UV) absorbents in plastic food contact materials. The separation was optimized by employing different chromatographic conditions including stationary phases, organic modifiers, column temperatures and back pressures to achieve appropriate selectivity and resolution. The 14 UV absorbents were analyzed within 4.5 min on the sub-2-micron particles column (ACQUTY UPC2 HSS C18 SB) via gradient elution with methanol as the organic modifier. The calibrations were carried out in the concentration range of 0.1–50.0 mg/L (except for UV-329 and UV-320 were 0.2–50.0 mg/L, UV-360 was 0.3–50.0 mg/L), and excellent linearity was observed with correlation coefficients (R2) greater than 0.99. The limits of quantification (LOQ) were in the range of 0.10–0.30 µg/g. The recoveries for accuracy were ranged from 90.4 to 114.1%, and the relative standard deviation (RSD) for repeatability was between 0.67 and 7.23%, respectively. The established method was successfully applied for the analysis of UV absorbents in five plastic food contact materials samples. The SFC method developed in this study can provide an alternative route for routine analysis of UV absorbents in the future. Graphical Abstract

中文翻译：

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亚 2 微米颗粒超临界流体色谱法快速分析塑料食品接触材料中的 14 种紫外线吸收剂

摘要 建立了一种基于超临界流体色谱 (SFC) 技术的快速、可靠的方法，用于分析塑料食品接触材料中的 14 种紫外线 (UV) 吸收剂。通过采用不同的色谱条件（包括固定相、有机改性剂、柱温和背压）来优化分离，以实现适当的选择性和分离度。在亚 2 微米颗粒色谱柱 (ACQUTY UPC2 HSS C18 SB) 上，通过使用甲醇作为有机改性剂的梯度洗脱，在 4.5 分钟内分析了 14 种紫外线吸收剂。在 0.1–50.0 mg/L 的浓度范围内进行校准（除 UV-329 和 UV-320 为 0.2–50.0 mg/L，UV-360 为 0.3–50.0 mg/L），优异的线性度为观察到相关系数 (R2) 大于 0.99。定量限 (LOQ) 范围为 0.10–0.30 µg/g。准确度回收率为 90.4% 至 114.1%，重复性相对标准偏差 (RSD) 分别为 0.67% 至 7.23%。所建立的方法已成功应用于五种塑料食品接触材料样品中紫外线吸收剂的分析。本研究开发的 SFC 方法可为未来紫外线吸收剂的常规分析提供替代途径。图形概要 本研究开发的 SFC 方法可为未来紫外线吸收剂的常规分析提供替代途径。图形概要 本研究中开发的 SFC 方法可为未来紫外线吸收剂的常规分析提供替代途径。图形概要