Abstract Imino-quinolyl Schiff-base ligands have been prepared by the condensation reaction of substituted 2-aminopyridine and quinoline-2-carbaldehyde. The reaction of [(arene)MCl2]2 with imino-quinolyl Schiff-base ligands leads to the formation of cationic complexes [(arene)M(L)Cl]+ (1–12). Single crystal X-ray diffraction studies were used to confirm the coordination mode and structures of these complexes. The molecular structures of these complexes revealed that they adopt characteristic three-legged piano stool geometry with the metal coordinating through a terminal chloride and imino-quinolyl ligands in a bidentate chelating NN′ fashion. The ligand coordinates to the metal center through the nitrogen of the quinoline and the imine nitrogen forming a five-membered metallacycle. These compounds were evaluated for their in vitro antibacterial activity by the agar well diffusion method against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae strains. Results show that all the ligands and complexes inhibited the growth of bacteria. Graphical Abstract

中文翻译：

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含亚氨基-喹啉配体的芳烃铂族金属配合物：合成和抗菌研究

摘要 通过取代的2-氨基吡啶与喹啉-2-甲醛的缩合反应制备了亚氨基-喹啉基席夫碱配体。[(芳烃) MCl2]2 与亚氨基-喹啉基席夫碱配体的反应导致形成阳离子配合物 [(芳烃)M(L)Cl]+ (1-12)。单晶 X 射线衍射研究用于确认这些配合物的配位模式和结构。这些配合物的分子结构表明，它们采用特征性的三足钢琴凳几何形状，金属通过末端氯化物和亚氨基-喹啉配体以双齿螯合 NN' 方式配位。配体通过喹啉的氮和亚胺氮与金属中心配位，形成五元金属环。通过琼脂井扩散法对这些化合物对金黄色葡萄球菌、大肠杆菌和肺炎克雷伯菌菌株的体外抗菌活性进行了评估。结果表明所有配体和复合物均抑制细菌的生长。图形概要