Abstract

One new spirocyclic lactone, terreinlactone C (1), and one new benzopyran derivative, 2,2-dimethyl-3-hydroxychroman-6-aldehyde (2), were discovered from the fungus Aspergillus terreus. The chemical structures of compounds 1 and 2 were elucidated by detailedly analyzing NMR and HRESIMS data. Compound 1 is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway is proposed. Two compounds were tested for their cytotoxic activities against five human cancer cell lines.

中文翻译：

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一种来自土曲霉的新的螺环内酯和一种新的苯并吡喃衍生物

摘要

从真菌曲霉中发现了一种新的螺环内酯，terreinlactone C（1）和一种新的苯并吡喃衍生物2,2-二甲基-3-羟基苯并二氢吡喃-6-醛（2）。通过详细分析NMR和HRESIMS数据，阐明了化合物1和2的化学结构。化合物1是第一个具有1-oxaspiro [4.5] decan-2-one环系统的天然产物，并提出了可能的生物遗传途径。测试了两种化合物对五种人类癌细胞系的细胞毒活性。