Abstract

Two new pyrrolizidine alkaloids, sclerwalins A and B (1 and 2), and one known 9-O-E-hydroxysenecioylretronecine (3) were first isolated from the seeds of Scleropyrum wallichianum. Their chemical structures were elucidated by extensive 1 D NMR and 2 D NMR (HSQC, HMBC, COSY, and ROESY), MS and IR spectra. Cytotoxicities of all isolates were evaluated against five human tumor cell lines (HL-60, A-549, SMMC-7721, MCF-7 and SW480).

中文翻译：

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壁枝菌核种子中的吡咯烷核生物碱

摘要

首先从Scleropyrum wallichianum的种子中分离出了两种新的吡咯并立柱生物碱，巩膜蛋白A和B（1和2），以及一种已知的9- OE-羟基千里光烯基维甲酸（3）。通过广泛的1 D NMR和2 D NMR（HSQC，HMBC，COSY和ROESY），MS和IR光谱阐明了它们的化学结构。评估了所有分离物对五种人类肿瘤细胞系（HL-60，A-549，SMMC-7721，MCF-7和SW480）的细胞毒性。