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Pyrrolizidine alkaloids from the seeds of Scleropyrum wallichianum
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2020-03-31 , DOI: 10.1080/10286020.2020.1740919
Jun-Hong Liu 1 , Han Yang 1, 2 , Ling Zhang 1, 3 , Xing-Rong Peng 1 , Zhen-Jie Li 1, 3 , Mei-Ying He 4 , Luo-Sheng Wan 1 , Zhong-Rong Li 1 , Lin Zhou 3 , Zhi-Hua Liu 3 , Ming-Hua Qiu 1, 2
Affiliation  

Abstract

Two new pyrrolizidine alkaloids, sclerwalins A and B (1 and 2), and one known 9-O-E-hydroxysenecioylretronecine (3) were first isolated from the seeds of Scleropyrum wallichianum. Their chemical structures were elucidated by extensive 1 D NMR and 2 D NMR (HSQC, HMBC, COSY, and ROESY), MS and IR spectra. Cytotoxicities of all isolates were evaluated against five human tumor cell lines (HL-60, A-549, SMMC-7721, MCF-7 and SW480).



中文翻译:

壁枝菌核种子中的吡咯烷核生物碱

摘要

首先从Scleropyrum wallichianum的种子中分离出了两种新的吡咯并立柱生物碱,巩膜蛋白A和B(12),以及一种已知的9- OE-羟基千里光烯基维甲酸(3)。通过广泛的1 D NMR和2 D NMR(HSQC,HMBC,COSY和ROESY),MS和IR光谱阐明了它们的化学结构。评估了所有分离物对五种人类肿瘤细胞系(HL-60,A-549,SMMC-7721,MCF-7和SW480)的细胞毒性。

更新日期:2020-03-31
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