Systemic lupus erythematosus (SLE), an autoimmune disease that causes multiorgan injury, has an unclear etiology and complex pathogenesis. Numerous studies have found abnormal alterations in mRNAs, proteins and/or metabolites in SLE patients. These findings have extended our understanding of the pathogenesis of SLE. Novel omics techniques, such as transcriptome, proteome and metabolome profiling, can identify and quantify large numbers of biomarkers of human diseases. However, in most cases, biological reactions are the consequences of interactions among genes, proteomes, and metabolites. Single biomolecules or signaling pathways cannot fully explain biological traits or functions. Therefore, integrative multi-omics analysis can help us systematically comprehend the intrinsic molecular mechanisms underlying biological function and pathogenesis. Integrating transcriptome, proteome, and metabolome KEGG enrichment analysis data will expand our knowledge of the pathogenesis of SLE. This review discusses the application, research progress and outlook on integrative multi-omics analysis in SLE research.

系统性红斑狼疮（SLE）是一种引起多器官损伤的自身免疫性疾病，病因尚不清楚，发病机理也很复杂。大量研究发现，SLE患者的mRNA，蛋白质和/或代谢产物发生异常改变。这些发现扩展了我们对SLE发病机制的认识。诸如转录组，蛋白质组和代谢组图谱之类的新型组学技术可以识别和量化人类疾病的大量生物标志物。但是，在大多数情况下，生物反应是基因，蛋白质组和代谢物之间相互作用的结果。单一生物分子或信号通路无法完全解释生物学特性或功能。因此，综合多组学分析可以帮助我们系统地理解生物学功能和发病机理的内在分子机制。整合转录组，蛋白质组和代谢组KEGG富集分析数据将扩展我们对SLE发病机制的了解。本文综述了整合多组学分析在SLE研究中的应用，研究进展和展望。