ABSTRACT

Background: Tumor necrosis factor superfamily member 4 (TNFSF4) has significant role in modulating autoimmune diseases (ADs) and single nucleotide polymorphism (SNP) is also related with the susceptibility to some diseases. So a meta-analysis aimed at systematically assessing the associations between TNFSF4 polymorphisms (rs2205960 G > A, rs704840 T > G and rs844648 G > A) and ADs risk was performed in Asians. Methods: Total 14 eligible articles published before March 2019 involving 35 studies, of which 21 studies (16,109 cases and 26,378 controls) for rs2205960 G > A, 8 studies (2,424 cases and 3,692 controls) for rs704840 T > G, and 6 studies (3,839 cases and 5,867 controls) for rs844648 G > A were included. Effects of the three respective polymorphisms on the susceptibility to ADs were estimated by pooling the odds ratios (ORs) with their corresponding 95% confidence interval (95% CI) in allelic, dominant, recessive, heterozygous and homozygous models. Results: The overall analysis revealed that all the rs2205960 G > A, rs704840 T > G and rs844648 G > A polymorphisms could increase the risk of ADs in allelic, dominant, recessive, heterozygous and homozygous models. Furthermore, subgroup analysis showed that both rs2205960 G > A and rs704840 T > G were significantly associated with the susceptibility to systemic lupus erythematosus (SLE). What’s more, statistically significant association between rs2205960 G > A polymorphism and primary Sjögren’s syndrome (pSS) susceptibility was also observed in allelic, dominant and heterozygous models. Conclusions: This current meta-analysis suggested that all of the three TNFSF4 polymorphisms may be associated with ADs susceptibility in Asians.

摘要

背景：肿瘤坏死因子超家族成员 4 (TNFSF4) 在调节自身免疫性疾病 (ADs) 中具有重要作用，单核苷酸多态性 (SNP) 也与对某些疾病的易感性有关。因此，一项荟萃分析旨在系统地评估TNFSF4在亚洲人中进行了多态性（rs2205960 G > A、rs704840 T > G 和 rs844648 G > A）和 AD 风险。方法：2019 年 3 月之前发表的共 14 篇符合条件的文章，涉及 35 项研究，其中 rs2205960 G > A 的 21 项研究（16,109 个病例和 26,378 个对照），rs704840 T > G 的 8 项研究（2,424 个病例和 3,692 个对照）和 6 个研究（ rs844648 G > A 的 3,839 个病例和 5,867 个对照被包括在内。通过在等位基因、显性、隐性、杂合和纯合模型中将比值比 (OR) 与其相应的 95% 置信区间 (95% CI) 合并来估计三个各自多态性对 AD 易感性的影响。结果：总体分析表明，rs2205960 G > A、rs704840 T > G 和 rs844648 G > A 多态性均可增加等位基因、显性、隐性、杂合和纯合模型。此外，亚组分析显示 rs2205960 G > A 和 rs704840 T > G 均与系统性红斑狼疮 (SLE) 的易感性显着相关。此外，在等位基因、显性和杂合模型中还观察到 rs2205960 G > A 多态性与原发性干燥综合征 (pSS) 易感性之间的统计学显着关联。结论：目前的荟萃分析表明，所有三个 在等位基因、显性和杂合模型中也观察到多态性和原发性干燥综合征 (pSS) 易感性。结论：目前的荟萃分析表明，所有三个 在等位基因、显性和杂合模型中也观察到多态性和原发性干燥综合征 (pSS) 易感性。结论：目前的荟萃分析表明，所有三个TNFSF4多态性可能与亚洲人的 AD 易感性有关。