Introduction

The treatment performances of current surgical therapeutic materials for injuries caused by high-energy trauma, such as prolonged bone defects, nerve-fiber disruptions, and repeated spasms or adhesions of vascular tendons after repair, are poor. Drug-loaded electrospun fibers have become a novel polymeric material for treating orthopedic diseases owing to their three-dimensional structures, thus providing excellent controlled drug-release responses and high affinity with local tissues. Herein, we reviewed the morphology of electrospun nanofibers, methods for loading drugs on the fibers, and modification methods to improve drug permeability and bioavailability. We highlight innovative applications of drug-loaded electrospun fibers in different treatments, including bone and cartilage defects, tendon and soft-tissue adhesion, vascular remodeling, skin grafting, and nervous-system injuries.

Areas covered

With the rapid development of electrospinning technologies and advancement of tissue engineering, drug-loaded electrospun fibers are becoming increasingly important in controlled drug release, wound closure, and tissue regeneration and repair.

Expert opinion

Drug-loaded electrospun fibers exhibit a broad range of application prospects and great potential in treating orthopedic diseases. Accordingly, a plethora of novel treatments utilizing the different morphological features of electrospun fibers, the distinctive pharmacokinetics, pharmacodynamics characteristics of different drugs, and the diverse onset characteristics of different diseases, is proposed.

中文翻译：

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电纺纤维：一种用于治疗骨疾病的创新输送方法。

介绍

当前的外科手术治疗材料对于由高能创伤引起的损伤的治疗性能较差，所述高能创伤例如是长时间的骨缺损，神经纤维断裂以及修复后血管肌腱反复痉挛或粘附。由于其三维结构，载有药物的电纺纤维已成为治疗骨科疾病的新型聚合材料，因此可提供出色的受控药物释放反应和与局部组织的高亲和力。本文中，我们综述了电纺纳米纤维的形态，在纤维上加载药物的方法以及提高药物渗透性和生物利用度的改性方法。我们着重介绍载药电纺纤维在不同治疗方法中的创新应用，包括骨骼和软骨缺损，肌腱和软组织粘附，血管重塑，

覆盖区域

随着电纺技术的迅速发展和组织工程学的发展，载药电纺纤维在控制药物释放，伤口闭合以及组织再生和修复中变得越来越重要。

专家意见

载药电纺纤维具有广阔的应用前景，在骨科疾病的治疗上具有巨大的潜力。因此，提出了许多利用电纺纤维的不同形态特征，不同药物的独特药代动力学，药效学特征以及不同疾病的不同发作特征的新颖治疗方法。