SummaryThis study aimed to describe outcomes in four women aged 28–34 years with central cytoplasmic granulation (CCG) of the oocytes who underwentin vitrofertilization/intracytoplasmic sperm injection (ICSI) using gonadotrophin-releasing hormone (GnRH) agonist to replace human chorionic gonadotrophin (hCG) as a trigger of final oocyte maturation. The initial ICSI procedure showed that all four women had CCG of the ooplasm and poor quality embryos. Subsequent ICSI used an antagonist protocol with a GnRH agonist trigger replacing the agonist protocol, plus hCG triggered ovulation. Ooplasm and embryo quality were improved in all four patients. All four became pregnant and gave birth to live infants. This study provides GnRH agonist triggering that may improve ooplasm granularity and embryo quality.

中文翻译：

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促性腺激素释放激素激动剂触发可改善中央卵母细胞粒度和胚胎质量

摘要本研究旨在描述 4 名 28-34 岁的卵母细胞中央细胞质肉芽 (CCG) 女性接受体外使用促性腺激素释放激素 (GnRH) 激动剂替代人绒毛膜促性腺激素 (hCG) 作为最终卵母细胞成熟的触发因素的受精/胞浆内精子注射 (ICSI)。最初的 ICSI 程序显示，所有四名女性都有卵质 CCG 和质量差的胚胎。随后的 ICSI 使用了拮抗剂方案，其中 GnRH 激动剂触发取代了激动剂方案，加上 hCG 触发了排卵。所有四名患者的卵质和胚胎质量均得到改善。这四个人都怀孕并生下了活婴儿。该研究提供了可以改善卵质粒度和胚胎质量的 GnRH 激动剂触发。