BackgroundObsessive-compulsive disorder (OCD) and tic disorder (TD) represent highly disabling, chronic and often comorbid psychiatric conditions. While recent studies showed a high risk of suicide for patients with OCD, little is known about those patients with comorbid TD (OCTD). Aim of this study was to characterize suicidal behaviors among patients with OCD and OCTD.MethodsThree hundred and thirteen outpatients with OCD (n = 157) and OCTD (n = 156) were recruited from nine different psychiatric Italian departments and assessed using an ad-hoc developed questionnaire investigating, among other domains, suicide attempt (SA) and ideation (SI). The sample was divided into four subgroups: OCD with SA (OCD-SA), OCD without SA (OCD-noSA), OCTD with SA (OCTD-SA), and OCTD without SA (OCTD-noSA).ResultsNo differences between groups were found in terms of SI, while SA rates were significantly higher in patients with OCTD compared to patients with OCD. OCTD-SA group showed a significant male prevalence and higher unemployment rates compared to OCD-SA and OCD-noSA sample. Both OCTD-groups showed an earlier age of psychiatric comorbidity onset (other than TD) compared to the OCD-SA sample. Moreover, patients with OCTD-SA showed higher rates of other psychiatric comorbidities and positive psychiatric family history compared to the OCD-SA group and to the OCD-noSA groups. OCTD-SA and OCD-SA samples showed higher rates of antipsychotics therapies and treatment resistance compared to OCD-noSA groups.ConclusionsPatients with OCTD vs with OCD showed a significantly higher rate of SA with no differences in SI. In particular, OCTD-SA group showed different unfavorable epidemiological and clinical features which need to be confirmed in future prospective studies.

中文翻译：

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强迫性抽动相关障碍与强迫症患者的自杀意念和自杀企图：意大利多中心研究的结果

背景强迫症 (OCD) 和抽动障碍 (TD) 代表了高度致残、慢性和经常合并的精神疾病。虽然最近的研究表明强迫症患者的自杀风险很高，但对那些患有 TD 共病 (OCTD) 的患者知之甚少。本研究的目的是描述强迫症和强迫症患者的自杀行为。方法从意大利九个不同的精神病科招募了 313 名强迫症 (n = 157) 和 OCTD (n = 156) 门诊患者，并使用特设开发了问卷调查，除其他领域外，自杀未遂（SA）和想法（SI）。样本分为四个亚组：强迫症伴 SA（OCD-SA）、强迫症不伴 SA（OCD-noSA）、OCTD 伴 SA（OCTD-SA）和 OCTD 不伴 SA（OCTD-noSA）。结果在SI方面未发现组间差异，而OCTD患者的SA率显着高于OCD患者。与 OCD-SA 和 OCD-noSA 样本相比，OCTD-SA 组显示出显着的男性患病率和更高的失业率。与 OCD-SA 样本相比，两个 OCTD 组都显示出更早的精神疾病发病年龄（TD 除外）。此外，与 OCD-SA 组和 OCD-noSA 组相比，OCTD-SA 患者的其他精神病合并症和阳性精神病家族史的发生率更高。与 OCD-noSA 组相比，OCTD-SA 和 OCD-SA 样本显示出更高的抗精神病药物治疗率和治疗抵抗率。结论 OCTD 与 OCD 患者的 SA 发生率显着更高，而 SI 无差异。特别是，