Here, we explored the influences of dietary inulin (INU) supplementation on growth performance and intestinal health in a porcine model. Thirty-two male weaned pigs (with an average body weight of 7·10 (sd 0·20) kg) were randomly assigned to four treatments and fed with a basal diet (BD) or BD containing 2·5, 5·0 and 10·0 g/kg INU. After a 21-d trial, pigs were killed for collection of serum and intestinal tissues. We show that INU supplementation had no significant influence on the growth performance in weaned pigs. INU significantly elevated serum insulin-like growth factor-1 concentration but decreased diamine oxidase concentration (P < 0·05). Interestingly, 2·5 and 5·0 g/kg INU supplementation significantly elevated the villus height in jejunum and ileum (P < 0·05). Moreover, 2·5 and 5·0 g/kg INU supplementation also elevated the villus height to crypt depth (V:C) in the duodenum and ileum and improved the distribution and abundance of tight-junction protein zonula occludens-1 in duodenum and ileum epithelium. INU supplementation at 10·0 g/kg significantly elevated the sucrase activity in the ileum mucosa (P < 0·05). INU supplementation decreased the expression level of TNF-α but elevated the expression level of GLUT 2 and divalent metal transporter 1 in the intestinal mucosa (P < 0·05). Moreover, INU increased acetic and butyric acid concentrations in caecum (P < 0·05). Importantly, INU elevated the Lactobacillus population but decreased the Escherichia coli population in the caecum (P < 0·05). These results not only indicate a beneficial effect of INU on growth performance and intestinal barrier functions but also offer potential mechanisms behind the dietary fibre-regulated intestinal health.

中文翻译：

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日粮添加菊粉对断奶仔猪生长性能、肠道屏障完整性和微生物种群的影响

在这里，我们在猪模型中探讨了膳食菊粉 (INU) 补充剂对生长性能和肠道健康的影响。断奶公猪32头（平均体重7·10（sd0·20) kg) 被随机分配到 4 个处理组并饲喂基础日粮 (BD) 或含有 2·5、5·0 和 10·0 g/kg INU 的 BD。在 21 天的试验后，将猪处死以收集血清和肠组织。我们表明，INU 补充剂对断奶猪的生长性能没有显着影响。INU显着升高血清胰岛素样生长因子-1浓度，但降低二胺氧化酶浓度（磷< 0·05)。有趣的是，补充 2·5 和 5·0 g/kg INU 显着提高了空肠和回肠的绒毛高度（磷< 0·05)。此外，补充 2·5 和 5·0 g/kg INU 还提高了十二指肠和回肠中绒毛高度与隐窝深度 (V:C) 的关系，并改善了十二指肠和回肠中紧密连接蛋白 zonula occludens-1 的分布和丰度。回肠上皮。以 10·0 g/kg 补充 INU 显着提高了回肠黏膜中的蔗糖酶活性（磷< 0·05)。补充 INU 可降低 TNF- 的表达水平α但升高了肠黏膜中 GLUT 2 和二价金属转运蛋白 1 的表达水平（磷< 0·05)。此外，INU 增加了盲肠中的乙酸和丁酸浓度（磷< 0·05)。重要的是，INU 提高了乳酸杆菌人口却减少了大肠杆菌盲肠中的人口（磷< 0·05)。这些结果不仅表明 INU 对生长性能和肠道屏障功能的有益影响，而且还提供了膳食纤维调节肠道健康的潜在机制。