Abstract

The impact of prediabetes and diabetes on skeletal health in the context of increased risk of fragility fractures in adults has been studied recently. However, the prevalence of diabetes, overweight, and obesity have also increased in younger subjects. Current data concerning bone metabolism based on assessment of markers for bone turnover and of bone quality in diabetes patients in diverse age groups appears to be inconsistent. This review synthesizes the current data on the assessment of bone turnover based on the use of circulating bone markers recommended by international organizations; the effects of age, gender, and other factors on the interpretation of the data; and the effects of type 1 and type 2 diabetes as well as hyperglycemia on bone quality and turnover with particular emphasis on the pediatric population. Early intervention in the pediatric population is necessary to prevent the progression of metabolic disturbances that accompany prediabetes and diabetes in the context of common low vitamin D status that may interfere with bone growth.

摘要

最近研究了在成人易碎性骨折风险增加的情况下，前驱糖尿病和糖尿病对骨骼健康的影响。但是，年轻受试者中糖尿病，超重和肥胖的患病率也有所增加。基于评估不同年龄组糖尿病患者骨转换和骨质量的标志物有关骨代谢的最新数据似乎不一致。这篇综述基于国际组织推荐的循环骨标记物的使用，综合了当前有关骨转换评估的数据；年龄，性别和其他因素对数据解释的影响；以及1型和2型糖尿病以及高血糖对骨质量和周转率的影响，特别是儿科人群。