Nephrotoxicity is a significant side effect of doxorubicin (DXN) treatment. We investigated the protective effect of gemfibrozil (GEM) co-administration with DXN on DXN induced nephrotoxicity. We divided 28 male Wistar rats into four groups of seven. Group 1 received normal saline for 2 weeks. Group 2 received 15 mg/kg DXN for 2 weeks. Group 3 received DXN + GEM for 2 weeks. Group 4 received GEM for 2 weeks. On day 15 of the experiment, blood samples were collected, animals were sacrificed and kidneys were excised for biochemical and histological evaluation. We measured serum creatinine, blood urine nitrogen, renal malondialdehyde, nitric oxide, glutathione, superoxide dismutase, glutathione peroxidase, catalase, tumor necrosis factor-α and interleukin-1β. GEM administration mitigated DXN induced nephrotoxicity. GEM co-administered with DXN attenuated the inflammatory and oxidative responses associated with DXN induced nephrotoxicity.

肾毒性是阿霉素（DXN）治疗的重要副作用。我们调查了吉非贝齐（GEM）与DXN并用对DXN诱导的肾毒性的保护作用。我们将28只雄性Wistar大鼠分成四组，每组七个。第一组接受生理盐水2周。第2组接受15 mg / kg DXN治疗2周。第3组接受DXN + GEM训练2周。第4组接受GEM治疗2周。在实验的第15天，收集血液样品，处死动物并切除肾脏以进行生化和组织学评估。我们测量了血清肌酐，血尿氮，肾丙二醛，一氧化氮，谷胱甘肽，超氧化物歧化酶，谷胱甘肽过氧化物酶，过氧化氢酶，肿瘤坏死因子-α和白介素-1β。GEM管理减轻了DXN诱导的肾毒性。