ABSTRACT

We investigated the effects of thymoquinone (TQ) on kidney tissues of Wistar rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced nephrotoxicity. We used 50 rats divided into five groups; control, corn oil, TCDD, TQ, TCDD + TQ. We found that malondialdehyde (MDA), total oxidant status (TOS), blood urea nitrogen (BUN), creatinine, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) levels in the TCDD treated group increased significantly compared to the other groups, while reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels decreased in the TCDD group. In the TQ treated group, we found that GSH, SOD, CAT, TAS levels increased and MDA, TOS, IL-6 and TNF-α levels decreased compared to the other groups. The effects of TCDD on oxidative stress parameters, inflammatory markers and histological changes were ameliorated by TQ treatment.

摘要

我们调查了2,3,7,8-四氯二苯并-p-二恶英（TCDD）诱导的肾毒性对Wistar大鼠肾脏组织中胸腺醌（TQ）的影响。我们将50只大鼠分为5组，每组5只。控制，玉米油，TCDD，TQ，TCDD + TQ。我们发现TCDD治疗组的丙二醛（MDA），总氧化剂状态（TOS），血尿素氮（BUN），肌酐，白介素6（IL-6），肿瘤坏死因子-α（TNF-α）水平显着增加与其他组相比，TCDD组的谷胱甘肽（GSH），超氧化物歧化酶（SOD），过氧化氢酶（CAT）和总抗氧化剂状态（TAS）含量降低。在TQ治疗组中，与其他组相比，我们发现GSH，SOD，CAT，TAS水平升高，而MDA，TOS，IL-6和TNF-α水平降低。TCDD对氧化应激参数的影响，