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Ternary encoded super-selective arterial spin labeling for time-resolved flow territory mapping.
Physics in Medicine & Biology ( IF 3.3 ) Pub Date : 2020-05-11 , DOI: 10.1088/1361-6560/ab7ef0
Thomas Lindner 1 , Olav Jansen , Michael Helle
Affiliation  

Arterial spin labeling (ASL) is a non-contrast enhanced method for perfusion measurements. The obtained information is in general a snap-shot of the whole-brain perfusion. Image acquisition is performed after a certain delay time after the labeling of the arterial blood. Time-resolved information alongside flow territory mapping of individual arteries can become useful for the collection of important information such as arterial crossflow, and revascularization. Therefore, a method is presented that combines time-resolved flow territory mapping within a single scan based on encoding of the acquisition cycle using a ternary matrix approach. The super-selective tagging process is divided in individual blocks following a ternary matrix encoding scheme. In each block, the position of the labeling focus changes its position to each of the major brain feeding arteries. Contrary to conventional ASL approaches, no control condition is acquired and the individual flow territories are calculated by combining the label images only. The method was successfully evaluated in healthy volunteers. Each flow territory could be visualized over several post labeling delays within a single scan of approximately five minutes. Comparison of signal intensity (relative perfusion) did not show statistically significant differences between the methods. Encoding super-selective ASL using a ternary matrix allows for the vessel-selective and time-resolved acquisition of perfusion territories within a single scan.

中文翻译:

三元编码的超选择性动脉自旋标记,用于时间分辨的流域映射。

动脉自旋标记(ASL)是一种无对比度的灌注测量方法。所获得的信息通常是全脑灌注的快照。在动脉血标记后的一定延迟时间后执行图像采集。时间分辨信息以及各个动脉的血流区域图对于收集重要信息(如动脉横流和血运重建)很有用。因此,提出了一种方法,该方法使用三元矩阵方法,基于采集周期的编码,在单次扫描中结合了时间分辨的流域映射。按照三元矩阵编码方案,将超选择性标记过程分为多个单独的块。在每个区块中 标记焦点的位置将其位置更改为每个主要的大脑喂养动脉。与传统的ASL方法相反,没有获取控制条件,并且仅通过组合标签图像来计算各个流域。该方法已在健康志愿者中成功评估。在大约五分钟的单次扫描中,可以在几次贴标延迟后可视化每个流动区域。信号强度的比较(相对灌注)在两种方法之间没有统计学上的显着差异。使用三元矩阵对超选择性ASL进行编码可以在一次扫描中对血管区域进行血管选择性和时间分辨采集。没有获取控制条件,并且仅通过组合标签图像来计算各个流域。该方法已在健康志愿者中成功评估。在大约五分钟的单次扫描中,可以在几次贴标延迟后可视化每个流动区域。信号强度的比较(相对灌注)在两种方法之间没有统计学上的显着差异。使用三元矩阵对超选择性ASL进行编码可以在一次扫描中对血管区域进行血管选择性和时间分辨采集。没有获取控制条件,并且仅通过组合标签图像来计算各个流域。该方法已在健康志愿者中成功评估。在大约五分钟的单次扫描中,可以在几次贴标延迟后可视化每个流动区域。信号强度的比较(相对灌注)在两种方法之间没有统计学上的显着差异。使用三元矩阵对超选择性ASL进行编码可以在一次扫描中对血管区域进行血管选择性和时间分辨采集。信号强度的比较(相对灌注)在两种方法之间没有统计学上的显着差异。使用三元矩阵对超选择性ASL进行编码,可以在一次扫描中对血管区域进行血管选择性和时间分辨采集。信号强度的比较(相对灌注)在两种方法之间没有统计学上的显着差异。使用三元矩阵对超选择性ASL进行编码可以在一次扫描中对血管区域进行血管选择性和时间分辨采集。
更新日期:2020-05-10
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