Pronounced elastic nonlinearity intrinsic to many biological tissues makes the Young’s modulus (stiffness) of the tissue strongly dependent on the current strain and stress. The measured modulus may vary several times for rather moderate tissue straining within a few per cent, such strains being quite typical for compressional optical coherence elastography (C-OCE). This pronounced stiffness variability may strongly affect diagnostic conclusions based on the stiffness measurements, so that obtaining reproducible estimates of stiffness in C-OCE is an important and challenging problem. Here, we report a novel full-optical method allowing one to ensure a preselected stress level in C-OCE stiffness mapping. The proposed improved OCE visualization enables reproducible quantitative elastographic visualization even for strongly elastically-nonlinear biological tissues, which is of key importance for reliability of diagnostic applications of C-OCE. In particular, in oncology such OCE te...

中文翻译：

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压缩应力光学相干弹性成像中排除非线性相关不确定性的局部模糊标准化全光方法

许多生物组织固有的明显的弹性非线性使组织的杨氏模量（刚度）强烈依赖于当前的应变和应力。对于适度的组织应变（在百分之几以内），测得的模量可能会变化几次，这种应变在压缩光学相干弹性成像（C-OCE）中非常典型。这种明显的刚度变化可能会严重影响基于刚度测量的诊断结论，因此获得C-OCE的可再现刚度估计值是一个重要且具有挑战性的问题。在这里，我们报告了一种新颖的全光学方法，可以确保C-OCE刚度映射中的预应力水平。所提出的改进的OCE可视化即使对于强弹性非线性生物组织也可以实现可重复的定量弹性成像可视化，这对于C-OCE诊断应用程序的可靠性至关重要。特别是在肿瘤学领域，这类OCE技术...