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Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation.
Journal of Food Biochemistry ( IF 1.662 ) Pub Date : 2020-05-11 , DOI: 10.1111/jfbc.13253
Suat Erdogan,Kader Turkekul

Cancer stem cells (CSCs) are one of the significant causes of cancer treatment failure and metastasis, as they have significant chemo‐and radio‐resistance leading to tumor recurrence. Here we investigated the possible anticancer properties of neferine, a natural alkaloid, on human prostate cancer (PCa) cells and their stem cells. CD44+ CSCs were isolated from androgen‐insensitive PC3 cells by magnetic‐activated cell sorting system (MACS). Neferine dose‐and time‐dependently inhibited the viability of PC3 and CSCs as well as androgen‐sensitive LNCaP cells through inducing apoptosis and cell cycle arrest at G1 phase. Neferine was shown to downregulate the expression of Bcl‐2 and CDK4, and upregulate caspase 3, clePARP, p21, p27, and p53. The treatment significantly inhibits the migration of CSCs. Neferine induces JNK and p38 MAPK phosphorylation, and downregulates PI3K and NF‐ĸβ signaling. In conclusion, neferine may have a therapeutic effect inhibiting the PCa cell proliferation as well as by eliminating CSCs.
更新日期:2020-07-06

 

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