Harmful effects of high amounts of glucose on the immune system: An updated review,Biotechnology and Applied Biochemistry

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Harmful effects of high amounts of glucose on the immune system: An updated review
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-05-12 , DOI: 10.1002/bab.1938
Navid Shomali _{1,

2,

3} , Javad Mahmoudi ₄ , Ata Mahmoodpoor ₅ , Reza Eghdam Zamiri ₁ , Morteza Akbari ₁ , Huaxi Xu ₆ , Siamak Sandoghchian Shotorbani _{1,

2,

6}

Affiliation

Release and storage of energy can be regulated by the metabolic parameter dependent on the central nervous system. Macrophages are one of the most professional antigen‐presenting cells that are formed by the accumulation of dead or damaged cells or in response to the infection, which has the main function of phagocytosis, secretion of cytokines, and presenting antigen to T cells. A proper immune response is needed for the production of effector cytokines along with comprehensive and rapid cell proliferation and growth. Activation of the immune system and immune cells is needed to increase glucose metabolism. When the immune system responds to pathogens, chemokines inform immune cells such as macrophages and T cells to travel to the infected area. Although glucose is vital for the proper function of immune cells and their proliferation, a high amount of glucose may lead to impaired function of the immune system and pathological conditions. However, a suitable amount of glucose is indispensable for the immune system, but its elevated amount leads to excessive proinflammatory cytokines production. In this study, we focused on the master regulatory role of glucose on the immune system.

中文翻译：

大量葡萄糖对免疫系统的有害影响：最新评论

能量的释放和储存可以通过取决于中枢神经系统的代谢参数来调节。巨噬细胞是最专业的抗原呈递细胞之一，由死细胞或受损细胞的积累或对感染的反应形成，具有吞噬作用，细胞因子的分泌以及向T细胞呈递抗原的主要功能。为了产生效应细胞因子以及全面而快速的细胞增殖和生长，需要适当的免疫应答。需要激活免疫系统和免疫细胞来增加葡萄糖代谢。当免疫系统对病原体做出反应时，趋化因子会通知免疫细胞（例如巨噬细胞和T细胞）传播到感染区域。尽管葡萄糖对于免疫细胞的正常功能及其增殖至关重要，大量的葡萄糖可能导致免疫系统功能和病理状况受损。但是，对于免疫系统必不可少的葡萄糖是必需的，但是葡萄糖的升高会导致过量的促炎性细胞因子产生。在这项研究中，我们集中于葡萄糖对免疫系统的主要调节作用。

更新日期：2020-05-12

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