Chronic low‐grade inflammation is one cause of follicle development disturbance. Chronic inflammation exists in pathological conditions such as premature ovarian failure, physiological aging of the ovaries, and polycystic ovary syndrome. Inflammation of the whole body can affect oocytes via the follicle microenvironment, oxidative stress, and GM‐CSF. Many substances without toxic side‐effects extracted from natural organisms have gradually gained researchers’ attention. Recently, chitosan oligosaccharide, resveratrol, anthocyanin, and melatonin have been found to contribute to an improvement in inflammation. This review discusses the interrelationships between chronic low‐grade inflammation and follicle development, the underlying mechanisms, and methods that may improve follicle development by controlling the level of chronic low‐grade inflammation.

中文翻译：

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控制慢性轻度炎症以改善卵泡发育和生存。

慢性低度炎症是导致卵泡发育障碍的原因之一。慢性炎症存在于病理状况中，例如卵巢早衰，卵巢的生理老化和多囊卵巢综合征。全身炎症可通过卵泡微环境，氧化应激和GM-CSF影响卵母细胞。从自然生物中提取的许多无毒副作用的物质已逐渐引起研究人员的注意。最近，已发现壳聚糖低聚糖，白藜芦醇，花色苷和褪黑激素有助于改善炎症。这篇综述讨论了慢性低度炎症和卵泡发育之间的相互关系，潜在机制，