Approximately a century after D'Arcy Thompson's On Growth and Form, there continues to be widespread interest in the biophysical and mathematical basis of morphogenesis. Particularly over the past 20 years, this interest has led to great advances in our understanding of a broad range of processes in embryonic development through a quantitative, mechanically driven framework. Nowhere in vertebrate development is this more apparent than the development of endodermally derived organs. Here, we discuss recent advances in the study of gut development that have emerged primarily from mechanobiology-motivated approaches that span from gut tube morphogenesis and later organogenesis of the respiratory and gastrointestinal systems.

中文翻译：

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脊椎动物肠道形态发生的力学生物学。

在达西·汤普森 (D'Arcy Thompson) 的《论生长与形态》(On Growth and Form) 发表大约一个世纪之后，人们对形态发生的生物物理学和数学基础继续广泛感兴趣。特别是在过去的 20 年里，这种兴趣使我们通过定量的、机械驱动的框架对胚胎发育的广泛过程的理解取得了巨大进步。在脊椎动物发育中，没有比内胚层衍生器官的发育更明显的了。在这里，我们讨论了肠道发育研究的最新进展，这些进展主要来自机械生物学驱动的方法，从肠管形态发生到后来的呼吸和胃肠系统的器官发生。