Neglect after stroke is most accurately diagnosed by a systematic, ecological observation during everyday behaviour using the Catherine Bergego Scale (CBS). However, the CBS is time-consuming and often omitted in clinical settings, especially stroke units. In this study, we aimed to explore if video-oculography during free visual exploration (FVE), which can be performed in few minutes, is sensitive in mirroring neglect in everyday behaviour and whether it is more sensitive than conventional neuropsychological paper-pencil tests. In this retrospective, observational, multicentre study, we identified 78 patients in our database with subacute right-hemispheric stroke, with and without neglect in everyday behaviour, diagnosed by the CBS, who also performed FVE. 40 age-matched healthy participants served as controls. The sensitivity to detect neglect was compared between FVE (i.e., mean gaze position on the horizontal axis) and conventional neuropsychological paper-pencil tests, i.e., Random Shape Cancellation, Line Bisection, Two-Part Picture, Bells, Star Cancellation, Letter Cancellation, Sensitive Neglect, and Five-Point. FVE correctly identified neglect in 85%of patients, with an AUC-value of .922 in ROC-analysis. Conventional neuropsychological paper-pencil tests, considered alone or in combination, showed heterogeneous results, and identified neglect significantly less often (21.74%–68.75%). Moreover, there was a significant correlation between mean gaze position and CBS scores, providing evidence for the relationship between FVE and neglect in everyday behaviour. Furthermore, VLSM analyses suggested that the absence of a pathological rightward bias in FVE might depend on the integrity of the second branch of the right Superior Longitudinal Fascicle (SLF II), a white-matter tract connecting cortical areas critical for visual attention. Video-oculography during FVE has a high sensitivity and specificity to diagnose neglect after stroke and it is more sensitive than conventional neuropsychological paper-pencil tests. It can be performed in short time and has the potential to be used as a fast and accurate screening tool that allows the initiation of comprehensive neuropsychological diagnostics and therapy from early on.

使用Catherine Bergego量表（CBS）通过日常行为期间的系统，生态学观察可以最准确地诊断中风后的疏忽。但是，CBS非常耗时，在临床环境中，尤其是中风单位，通常会被忽略。在这项研究中，我们旨在探讨可以在几分钟内执行的自由视觉探索（FVE）期间的视频眼动术是否对日常行为中的镜像忽略敏感，以及它是否比传统的神经心理学纸铅笔测试更敏感。在这项回顾性，观察性，多中心研究中，我们从数据库中确定了78例亚急性右半球性卒中，日常行为是否有遗漏的患者，这些患者均由CBS诊断，并且也进行了FVE。40名年龄匹配的健康参与者作为对照。在FVE（即水平轴上的平均注视位置）与常规神经心理学纸铅笔测试（即随机形状消除，线对分，两部分图片，钟声，星形消除，字母消除，敏感的忽视和五点。FVE在ROC分析中正确识别出85％的患者被忽视，其AUC值为.922。传统的神经心理学纸笔测试，单独或组合考虑，结果均不相同，并且发现被忽视的几率显着降低（21.74％–68.75％）。此外，平均注视位置与CBS评分之间存在显着相关性，为FVE与日常行为中的忽视之间的关系提供了证据。此外，VLSM分析表明，FVE中没有病理性的向右偏斜可能取决于右上纵向束（SLF II）的第二分支的完整性，该第二分支是连接皮层区域的白色物质，对于视觉注意力至关重要。FVE期间的视频眼图术具有较高的敏感性和特异性，可诊断中风后的疏忽，并且比传统的神经心理学纸笔测试更为敏感。它可以在短时间内完成，并且有可能被用作快速准确的筛查工具，从而可以从早期开始全面的神经心理学诊断和治疗。FVE期间的视频眼图术具有较高的敏感性和特异性，可诊断中风后的疏忽，并且比传统的神经心理学纸笔测试更为敏感。它可以在短时间内完成，并有可能被用作快速，准确的筛查工具，从而可以从早期开始全面的神经心理学诊断和治疗。FVE期间的视频眼动术具有较高的灵敏度和特异性，可诊断中风后的疏忽，并且比传统的神经心理学纸铅笔测试更敏感。它可以在短时间内完成，并有可能被用作快速准确的筛查工具，从而可以从早期开始全面的神经心理学诊断和治疗。