BACKGROUND Fractional exhaled nitric oxide levels are related to various clinical diseases. This study investigated the associations between the clinical characteristics and the level of fractional exhaled nitric oxide in patients with adult congenital heart disease. METHODS AND RESULTS Fractional exhaled nitric oxide values were measured in 30 adult patients with stable congenital heart disease who had undergone right heart catheterization and 17 healthy individuals (controls). There was no significant difference in fractional exhaled nitric oxide values between patients with congenital heart disease and healthy controls. Depending on whether their fractional exhaled nitric oxide values were above or below the median value, patients with congenital heart disease were divided into two groups (low vs. high fractional exhaled nitric oxide groups). The relationship between fractional exhaled nitric oxide values and clinical characteristics was investigated. There was a higher percentage of patients with cyanosis in the low fractional exhaled nitric oxide group (50%) than in the high fractional exhaled nitric oxide group (7.1%). There was no significant difference in right heart catheterization data between the low and high fractional exhaled nitric oxide groups. The fractional exhaled nitric oxide value was correlated to the number of neutrophils in patients with cyanosis (r = 0.84 (N = 8), p = 0.005). CONCLUSIONS In this cohort of patients with adult congenital heart disease, lower levels of fractional exhaled nitric oxide corresponded to the presence of cyanosis.

中文翻译：

---

成人先天性心脏病的部分呼出气一氧化氮。

背景技术呼出的一氧化氮水平与各种临床疾病有关。这项研究调查了成人先天性心脏病患者临床特征与呼出气一氧化氮水平之间的关系。方法和结果在30例接受了右心导管检查的稳定先天性心脏病成年患者和17例健康人（对照组）中，测量了呼出气一氧化氮的分数。先天性心脏病患者与健康对照组之间呼出的一氧化氮分数无显着差异。先天性心脏病患者根据其呼出一氧化氮分数是高于还是低于中位数，将其分为两组（低呼出分数与高呼出分数一氧化氮组）。研究了呼出气一氧化氮分数与临床特征之间的关系。低分数呼出一氧化氮组（50％）的紫患者比例高于高分数呼出一氧化氮组（7.1％）。低和高分数呼出气一氧化氮组之间的右心导管检查数据没有显着差异。呼出气中一氧化氮的分数与发osis患者的中性粒细胞数量相关（r = 0.84（N = 8），p = 0.005）。结论在这个成年先天性心脏病患者队列中，较低水平的呼出气一氧化氮水平与发osis有关。低分数呼出一氧化氮组（50％）的紫患者比例高于高分数呼出一氧化氮组（7.1％）。低和高分数呼出气一氧化氮组之间的右心导管检查数据没有显着差异。呼出气中一氧化氮的分数与发osis患者的中性粒细胞数量相关（r = 0.84（N = 8），p = 0.005）。结论在这个成年先天性心脏病患者队列中，较低水平的呼出气一氧化氮水平与发osis有关。低分数呼出一氧化氮组（50％）的紫患者比例高于高分数呼出一氧化氮组（7.1％）。低和高分数呼出气一氧化氮组之间的右心导管检查数据没有显着差异。呼出气中一氧化氮的分数与发osis患者的中性粒细胞数量相关（r = 0.84（N = 8），p = 0.005）。结论在这个成年先天性心脏病患者队列中，较低水平的呼出气一氧化氮水平与发osis有关。低和高分数呼出气一氧化氮组之间的右心导管检查数据没有显着差异。呼出气中一氧化氮的分数与发osis患者的中性粒细胞数量相关（r = 0.84（N = 8），p = 0.005）。结论在这个成年先天性心脏病患者队列中，较低水平的呼出气一氧化氮水平与发osis有关。低和高分数呼出气一氧化氮组之间的右心导管检查数据没有显着差异。呼出气中一氧化氮的分数与发osis患者的中性粒细胞数量相关（r = 0.84（N = 8），p = 0.005）。结论在这个成年先天性心脏病患者队列中，较低水平的呼出气一氧化氮水平与发osis有关。