Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, probably because of late diagnosis and lack of treatment. There is a great need to discover a novel compound to improve the general prognosis of HCC. Phloretin (Ph) is an apple polyphenol that is effective in treating pathogenic conditions having oxidative stress as a common mechanism. This study evaluated the anticancer property of Ph. Comparison of the Ph group with the HCC group indicated that Ph supplementation helped improve serum biomarkers of liver cancer, liver functions and oxidative status and enhance histological and morphological appearance and gene expression. Our results clearly demonstrated that Ph supplementation induced an apparent chemopreventive effect against diethylnitrosamine-induced HCC, as manifested by a significant modulation of serum biomarkers of liver cancer, liver functions, oxidative status, along with restraining histological appearance and gene expression.

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苹果多酚维他命对肝细胞癌大鼠模型的抗癌作用

肝细胞癌（HCC）是世界范围内与癌症相关的死亡的主要原因，这可能是由于晚期诊断和缺乏治疗所致。迫切需要发现一种新型化合物来改善HCC的总体预后。荧光素（Phloretin，Ph）是一种苹果多酚，可有效治疗以氧化应激为常见机制的病原体。这项研究评估了Ph的抗癌特性。Ph组与HCC组的比较表明，补充Ph有助于改善肝癌的血清生物标志物，肝功能和氧化状态，并增强组织学和形态学外观以及基因表达。我们的结果清楚地表明，添加Ph可以明显地预防二乙基亚硝胺诱导的HCC的化学预防作用，