Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy associated with dysimmune processes, often related to a previous infectious exposure. During Italian severe acute respiratory syndrome coronavirus-2 outbreak, a woman presented with a rapidly progressive flaccid paralysis with unilateral facial neuropathy after a few days of mild respiratory symptoms. Coronavirus was detected by nasopharyngeal swab, but there was no evidence of its presence in her cerebrospinal fluid, which confirmed the typical albumin-cytological dissociation of GBS, along with consistent neurophysiological data. Despite immunoglobulin infusions and intensive supportive care, her clinical picture worsened simultaneously both from the respiratory and neurological point of view, as if reflecting different aspects of the same systemic inflammatory response. Similar early complications have already been observed in patients with para-infectious GBS related to Zika virus, but pathological mechanisms have yet to be established.

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2019 年冠状病毒病 (COVID-19) 中的早期格林-巴利综合征：意大利 COVID 医院的病例报告。

格林-巴利综合征 (GBS) 是一种与免疫异常过程相关的急性多发性神经根神经病，通常与先前的感染暴露有关。在意大利严重急性呼吸综合征冠状病毒 2 型爆发期间，一名妇女在几天的轻微呼吸道症状后出现快速进展的弛缓性麻痹和单侧面部神经病变。通过鼻咽拭子检测到冠状病毒，但在她的脑脊液中没有发现其存在的证据，这证实了 GBS 的典型白蛋白-细胞学分离，以及一致的神经生理学数据。尽管进行了免疫球蛋白输注和强化支持治疗，但从呼吸系统和神经系统的角度来看，她的临床表现同时恶化，似乎反映了同一全身炎症反应的不同方面。