We determined isavuconazole serum concentrations for 150 UK patients receiving standard isavuconazole dosing regimens, including serial therapeutic drug monitoring for several patients on prolonged therapy. Mean trough isavuconazole concentrations in these patients were virtually identical to those reported previously from clinical trials, although greater variability was seen in patients below 18 years of age. Serial monitoring in patients receiving prolonged therapy suggested gradual, near-linear accumulation of the drug over many weeks.

中文翻译：

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英国参考中心的伊沙康康唑治疗药物监测的经验教训。

我们确定了150名接受标准艾伐康唑剂量治疗方案的英国患者的艾伐康唑血清浓度，包括对数名接受长期治疗的患者进行系列治疗药物监测。尽管在18岁以下的患者中观察到更大的变异性，但是这些患者中的伊沙康康唑的平均谷值浓度实际上与先前从临床试验中报告的浓度相同。对接受长期治疗的患者进行的连续监测表明，该药物在数周内逐渐逐渐接近线性蓄积。