Evolutionary-based predictions imply that the premenstrual syndrome (PMS) affects women who failed to conceive while in biosocial conditions that allow immediate reproduction. We investigated how the PMS is related to the heart rate variability (HRV), a marker of general fitness and well-being. The HRV indices (SDNN and rMSSD) were calculated using resting ECGs of 113 physiologically fertile women and 64 women using hormonal contraception (HC users, HCu). The intensity of PMS symptoms was self-assessed (Shortened Premenstrual Assessment Form). Analyses were conducted using parametric and nonparametric tests and general linear modelling (GLM). In HC non-users (HCnu), a greater intensity of PMS symptoms was significantly associated with higher values of HRV. Similar relations were not present in HCu. Post-hoc GLM confirmed that the relation between the PMS intensity and HRV indices varies as a function of the HCu status. A positive association between the PMS intensity and high HRV indices in women who did not use HC may confirm that the PMS affects fertile women who did not conceive, despite being in conditions favorable to pregnancy. The absence of a similar link in HCu women implies that synthetic steroids may disturb the link between the PMS and functioning of the autonomic nervous system.

中文翻译：

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年轻健康女性经前期综合征与静息心脏迷走神经张力的关系：激素避孕的作用

基于进化的预测意味着经前综合症 (PMS) 会影响在允许立即繁殖的生物社会条件下未能怀孕的女性。我们调查了 PMS 如何与心率变异性 (HRV) 相关，心率变异性是一般健康和幸福的标志。HRV 指数（SDNN 和 rMSSD）是使用 113 名生理可育女性和 64 名使用激素避孕的女性（HC 使用者，HCu）的静息心电图计算得出的。PMS 症状的强度是自我评估的（缩短的经前评估表）。使用参数和非参数检验以及一般线性模型 (GLM) 进行分析。在 HC 非使用者 (HCnu) 中，更大强度的 PMS 症状与更高的 HRV 值显着相关。HCu 中不存在类似的关系。事后 GLM 证实 PMS 强度和 HRV 指数之间的关系作为 HCu 状态的函数而变化。在未使用 HC 的女性中，PMS 强度与高 HRV 指数之间的正相关可能证实 PMS 会影响未受孕的可育女性，尽管其条件有利于怀孕。HCu 女性中没有类似的联系意味着合成类固醇可能会干扰 PMS 与自主神经系统功能之间的联系。