Tissue engineering has emerged as an alternative approach to create bone tissue by growing cells on 3D scaffolding. The aim of this study was to synthesize a composite glass/chitosan (BG-CH) by using new salt leaching using powder (SLUP) process in order to control the porosity rate and then the chemical reactivity of the final product. SLUP process consists on the cavity creation with desired pore sizes. It does not require heat treatment. This process is based on washing out the NaCl particles used for that. It is due to its high solubility in aqueous media. This work focuses on the elaboration, physicochemical, and chemical reactivity studies of pure bioactive glass and bioactive glass associated with chitosan. A range of composite scaffolds with different bioactive glass/chitosan contents has been synthesized. NaCl with a distinct range size was used with the aim of optimizing the pore network. Obtained results show that the specific surface area and pore volume increase with increasing of chitosan and porogen content. The same observations for pore volume were registered. The obtained scaffolds had high porosity (90%) with good pore connectivity. SEM images revealed strong dependence of sizes and shapes of pores on the salt/composite ratios.

中文翻译：

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使用粉末（SLUP）工艺进行盐浸，用于生物材料应用中的玻璃/壳聚糖支架加工

组织工程学已经成为通过在3D支架上生长细胞来创建骨骼组织的替代方法。这项研究的目的是通过使用新的粉末盐浸法（SLUP）工艺来合成玻璃/壳聚糖（BG-CH）复合材料，以控制最终产品的孔隙率和化学反应性。SLUP工艺包括创建具有所需孔径的型腔。它不需要热处理。该过程基于洗出用于此的NaCl颗粒。这是由于其在水性介质中的高溶解度。这项工作的重点是纯生物活性玻璃和与壳聚糖相关的生物活性玻璃的精细化，物理化学和化学反应性研究。已合成了一系列具有不同生物活性玻璃/壳聚糖含量的复合支架。为了优化孔网络，使用了具有不同范围大小的NaCl。所得结果表明，比表面积和孔体积随着壳聚糖和致孔剂含量的增加而增加。记录了相同的孔体积观察值。所得支架具有高孔隙率（90％）和良好的孔连通性。SEM图像显示出孔的大小和形状对盐/复合物比率的强烈依赖性。