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Comparison of Bone Marrow Involvement with Bone Marrow Biopsy and PET–CT and Evaluation of Any Effects on Survival in Patients Diagnosed with Hodgkin and Non-Hodgkin Lymphoma
Indian Journal of Hematology and Blood Transfusion ( IF 0.9 ) Pub Date : 2020-05-04 , DOI: 10.1007/s12288-020-01284-x
Mesut Göçer 1 , Erdal Kurtoğlu 1
Affiliation  

We aimed to demonstrate whether PET–CT can replace bone marrow biopsy in detecting bone marrow involvement in subtypes of lymphoma. In addition, we aimed to also reveal whether there is a difference between the mean survival of patients with bone marrow involvement via PET–CT or biopsy. A total of 276 newly diagnosed lymphoma patients who underwent bone marrow biopsy and PET–CT prior to the treatment were scanned retrospectively. Bone marrow biopsy was used as the standard method to investigate the presence of bone marrow involvement in PET–CT. The relationship between bone marrow involvement and mean survival was compared using both methods. Out of the 276 patients, bone marrow involvement was detected with PET–CT and with biopsy, respectively in 56 patients (20.2%) and in 78 patients (28.2%). In terms of PET–CT’s accuracy with respect to revealing bone marrow involvement, the highest rates were achieved respectively in diffuse large B cell lymphoma (DLBCL) (87.4%) and Hodgkin lymphoma (HL) (77.7%). In both the PET–CT and bone marrow biopsy methods, Overall Survival (OS) was found to be significantly shorter in patients with involvement than in patients without involvement ( P : 0.001). PET–CT may replace bone marrow (BM) biopsy in detecting the bone marrow involvement in aggressive lymphoma subtypes such as DLBCL and HL. The presence of BM involvement at the time of diagnosis in both PET–CT and BM biopsy is associated with poor prognosis, and OS is short in this group.

中文翻译:

骨髓受累与骨髓活检和 PET-CT 的比较以及对诊断为霍奇金和非霍奇金淋巴瘤患者生存率的任何影响的评估

我们旨在证明 PET-CT 是否可以代替骨髓活检来检测淋巴瘤亚型的骨髓受累。此外,我们还旨在通过 PET-CT 或活检揭示骨髓受累患者的平均存活率是否存在差异。共有 276 名新诊断的淋巴瘤患者在治疗前接受了骨髓活检和 PET-CT 的回顾性扫描。骨髓活检被用作研究 PET-CT 中是否存在骨髓受累的标准方法。使用这两种方法比较骨髓受累与平均存活率之间的关系。在 276 名患者中,PET-CT 和活检检测到骨髓受累,分别为 56 名患者(20.2%)和 78 名患者(28.2%)。就 PET-CT 在显示骨髓受累方面的准确性而言,弥漫性大 B 细胞淋巴瘤 (DLBCL) (87.4%) 和霍奇金淋巴瘤 (HL) (77.7%) 的准确率最高。在 PET-CT 和骨髓活检方法中,发现受累患者的总生存期 (OS) 显着短于未受累患者 ( P : 0.001)。在检测侵袭性淋巴瘤亚型(如 DLBCL 和 HL)的骨髓受累情况时,PET-CT 可能会取代骨髓 (BM) 活检。在 PET-CT 和 BM 活检中诊断时存在 BM 受累与预后不良相关,并且该组的 OS 较短。在 PET-CT 和骨髓活检方法中,发现受累患者的总生存期 (OS) 显着短于未受累患者 ( P : 0.001)。在检测侵袭性淋巴瘤亚型(如 DLBCL 和 HL)的骨髓受累情况时,PET-CT 可能会取代骨髓 (BM) 活检。在 PET-CT 和 BM 活检中诊断时存在 BM 受累与预后不良相关,并且该组的 OS 较短。在 PET-CT 和骨髓活检方法中,发现受累患者的总生存期 (OS) 显着短于未受累患者 ( P : 0.001)。在检测侵袭性淋巴瘤亚型(如 DLBCL 和 HL)的骨髓受累情况时,PET-CT 可能会取代骨髓 (BM) 活检。在 PET-CT 和 BM 活检中诊断时存在 BM 受累与预后不良相关,并且该组的 OS 较短。
更新日期:2020-05-04
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