Witz et al. recently performed single-cell mother machine experiments to track growth and the replication cycle in E. coli. They analyzed the correlation structure of selected parameters using both their data and published data, and concluded that E. coli cell-size control is implemented at replication initiation, which challenged the newly emerged division-centric mechanism of cell-size control in bacteria. We repeated Witz et al.’s analysis, and performed additional experiments and analytical calculations. These results explain Witz et al.’s observation and in fact support the division-centric model.

中文翻译：

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评论“染色体复制的启动通过双加器机制控制了大肠杆菌的分裂和复制周期”

Witz等。最近进行了单细胞母机实验，以追踪大肠杆菌的生长和复制周期。他们使用他们的数据和公开的数据分析了所选参数的相关结构，并得出结论认为，在复制起始时实施了大肠杆菌细胞大小控制，这挑战了细菌中以细胞为中心的新出现的以分裂为中心的机制。我们重复了Witz等人的分析，并进行了其他实验和分析计算。这些结果解释了Witz等人的观察，实际上支持了以分裂为中心的模型。