Background Modern antiretroviral therapies (ART) have decreased the prevalence of HIV-associated nephropathy (HIVAN). Nonetheless, we continue to see children and adolescents with HIVAN all over the world. Furthermore, once HIVAN is established in children, it is difficult to revert its long-term progression, and we need better animal models of childhood HIVAN to test new treatments.

中文翻译：

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儿童HIV相关性肾病的HIV-Tat诱导小鼠模型系统

背景技术现代抗逆转录病毒疗法（ART）降低了HIV相关肾病（HIVAN）的患病率。尽管如此，我们继续在世界各地看到患有HIVAN的儿童和青少年。此外，一旦在儿童中建立了HIVAN，就很难恢复其长期发展，我们需要更好的儿童HIVAN动物模型来测试新的治疗方法。