Background Leading to a sustained epidemic spread with >2,000,000 confirmed human infections, including >100,000 deaths, COVID-19 was caused by SARS-CoV-2 and resulted in acute respiratory distress syndrome (ARDS) and sepsis, which brought more challenges to the patient’s treatment. The S-glycoprotein, which recognized as the key factor for the entry of SARS-CoV-2 into the cell, contains two functional domains: an ACE2 receptor binding domain and a second domain necessary for fusion of the coronavirus and cell membranes. FURIN activity, exposes the binding and fusion domains, is essential for the zoonotic transmission of SARS-CoV-2. Moreover, it has been reported that ACE2 is likely to be the receptor for SARS-CoV-2. In addition, FURIN enzyme and ACE2 receptor were expressed in airway epithelia, cardiac tissue, and enteric canals, which considered as the potential target organ of the virus. However, report about the expression of FURIN and ACE2 in oral tissues was limited.

中文翻译：

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口腔上皮细胞中FURIN和ACE2的大量表达可能促进SARS-CoV-2进入的效率

背景COVID-19由SARS-CoV-2引起，导致持续的流行病蔓延，确诊的人类感染超过2,000,000，包括超过100,000的死亡，并导致了急性呼吸窘迫综合征（ARDS）和败血症，这给患者的治疗带来了更多挑战。被认为是SARS-CoV-2进入细胞的关键因素的S-糖蛋白包含两个功能域：一个ACE2受体结合域和一个冠状病毒与细胞膜融合所必需的第二域。FURIN活性（暴露结合域和融合域）对于SARS-CoV-2的人畜共患病传播至关重要。此外，据报道，ACE2可能是SARS-CoV-2的受体。此外，FURIN酶和ACE2受体在气道上皮，心脏组织和肠管中表达，被认为是该病毒的潜在靶器官。然而，有关口腔组织中FURIN和ACE2表达的报道有限。