Purpose: To demonstrate the value of smoothness index as a novel tool for quantitative analysis of iris surface findings in unilateral Fuchs uveitis (FU). Methods: In this observational study, both phakic eyes from patients with the diagnosis of unilateral FU were enrolled. All eyes underwent a complete ophthalmic examination and anterior segment optical coherence tomography(AS-OCT). The images were extracted and exported to the ImageJ software for calculating the smoothness index (SI). The SI was defined as ratio of length of the straight line connecting the most peripheral and the most central points of anterior iris surface to actual length of this boundary. Results: Forty eyes from 20 patients with unilateral FU were enrolled. Mean age of patients was 40+/-10 years. Mean overall SI was 0.876+/- 0.030 in eyes with FU that was significantly more than fellow control eyes (0.841+/-0.041). (p=0.005) The mean temporal and nasal SI were 0.878+/- 0.035 and 0.874+/- 0.033 in eyes with FU, compared to 0.843+/- 0.041 and 0.838+/- 0.047 in control fellow eyes, respectively. (p = 0.008 and p = 0.009, respectively) Conclusion: Iris smoothness index is a novel index to quantitatively document diffuse smoothness of iris anterior surface in eyes with FU. This index may facilitate diagnosis of subtle iris atrophic changes in these eyes, especially when heterochromia is absent.

中文翻译：

---

频谱域光学相干断层扫描技术在Fuchs葡萄膜炎中虹膜表面平滑度的定量分析

目的：证明平滑度指数作为定量分析单侧Fuchs葡萄膜炎（FU）虹膜表面发现的新型工具的价值。方法：在这项观察性研究中，纳入了诊断为单侧FU的双眼患者。所有的眼睛都经过了全面的眼科检查和前段光学相干断层扫描（AS-OCT）。提取图像并将其导出到ImageJ软件，以计算平滑度指数（SI）。SI定义为连接虹膜前表面的最外围和最中心点的直线的长度与该边界的实际长度的比值。结果：招募了20例单侧FU患者的40只眼。患者的平均年龄为40 +/- 10岁。平均整体SI为0.876 +/- 0。FU眼中的030明显高于其他对照眼（0.841 +/- 0.041）。（p = 0.005）患有FU的眼睛的平均颞叶和鼻腔SI分别为0.878 +/- 0.035和0.874 +/- 0.033，而对照组的眼睛分别为0.843 +/- 0.041和0.838 +/- 0.047。（分别为p = 0.008和p = 0.009）结论：虹膜平滑度指数是一种定量记录FU眼虹膜前表面弥散平滑度的新指标。该指数可能有助于诊断这些眼睛中细微的虹膜萎缩变化，尤其是在不存在异色症时。虹膜平滑度指数是一种新颖的指数，可定量地记录患有FU的眼睛虹膜前表面的弥散平滑度。该指数可能有助于诊断这些眼睛中细微的虹膜萎缩变化，尤其是在不存在异色症时。虹膜平滑度指数是一种新颖的指数，可定量地记录患有FU的眼睛虹膜前表面的弥散平滑度。该指数可能有助于诊断这些眼睛中细微的虹膜萎缩变化，尤其是在不存在异色症时。