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Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable
medRxiv - Genetic and Genomic Medicine Pub Date : 2020-04-24 , DOI: 10.1101/2020.04.22.20072124
Frances MK Williams , Maxim Freydin , Massimo Mangino , Simon Couvreur , Alessia Visconti , Ruth CE Bowyer , Caroline I Le Roy , Mario Falchi , Carole Sudre , Richard Davies , Christopher Hammond , Cristina Menni , Claire Steves , Tim Spector

Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n=2633) completing the C-19 Covid symptom tracker app allowed classical twin studies of covid-19 symptoms including predicted covid-19, a symptom-based algorithm predicting true infection derived in app users tested for SARS-CoV-2. We found heritability for fever = 41 (95% confidence intervals 12-70)%; anosmia 47 (27-67)%; delirium 49 (24-75)%; and predicted covid-19 gave heritability = 50 (29-70)%.

中文翻译:

covid-19的自我报告症状(包括最能预测SARS-CoV-2感染的症状)是可遗传的

感染的易感性(例如SARS-CoV-2)可能会受到宿主基因型的影响。TwinsUK志愿者(n = 2633)完成了C-19 Covid症状追踪器应用程序后,就可以对covid-19症状进行经典的双胞胎研究,包括预测的covid-19,这是一种基于症状的算法,可预测通过SARS-CoV-2测试的应用程序用户获得的真实感染。我们发现发烧的遗传力= 41(95%置信区间12-70)%;失眠症47(27-67)%; ir 49(24-75)%; 预测的covid-19的遗传力= 50(29-70)%。
更新日期:2020-04-24
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