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The phenotypic changes of γδ T cells in COVID-19 patients
medRxiv - Allergy and Immunology Pub Date : 2020-04-07 , DOI: 10.1101/2020.04.05.20046433 Lei Lei , Hongbo Qian , Xiaofang Yang , Xiaobo Zhou , Xingzhe Zhang , Dan Zhang , Tongxin Dai , Rui Guo , Lin Shi , Yanbin Cheng , Baojun Zhang , Jinsong Hu , Yaling Guo
medRxiv - Allergy and Immunology Pub Date : 2020-04-07 , DOI: 10.1101/2020.04.05.20046433 Lei Lei , Hongbo Qian , Xiaofang Yang , Xiaobo Zhou , Xingzhe Zhang , Dan Zhang , Tongxin Dai , Rui Guo , Lin Shi , Yanbin Cheng , Baojun Zhang , Jinsong Hu , Yaling Guo
A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which caused by SARS-CoV-2 and broken in Wuhan, China in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. Also, information regarding the immunological characteristics in COVID-19 patients remains limited. Here we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes in γδ T cells. In comparison to HD, the γδ T cells percentage was decreased. γδ T cells are able to immediately respond to SARS-CoV-2 infection and upregulate the activation marker CD25. In addition, the increased expression of CD4 in γδ T cells may serve as a biomarker for the assessment of SARS-CoV-2 infection.
更新日期：2020-04-07
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