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Crosstalk between Ubiquitination and Other Post-translational Protein Modifications in Plant Immunity
Plant Communications ( IF 9.4 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.xplc.2020.100041
Yi Zhang 1 , Lirong Zeng 1
Affiliation  

Post-translational modifications (PTMs) are central to the modulation of protein activity, stability, subcellular localization, and interaction with partners. They greatly expand the diversity and functionality of the proteome and have taken the center stage as key players in regulating numerous cellular and physiological processes. Increasing evidence indicates that in addition to a single regulatory PTM, many proteins are modified by multiple different types of PTMs in an orchestrated manner to collectively modulate the biological outcome. Such PTM crosstalk creates a combinatorial explosion in the number of proteoforms in a cell and greatly improves the ability of plants to rapidly mount and fine-tune responses to different external and internal cues. While PTM crosstalk has been investigated in depth in humans, animals, and yeast, the study of interplay between different PTMs in plants is still at its infant stage. In the past decade, investigations showed that PTMs are widely involved and play critical roles in the regulation of interactions between plants and pathogens. In particular, ubiquitination has emerged as a key regulator of plant immunity. This review discusses recent studies of the crosstalk between ubiquitination and six other PTMs, i.e., phosphorylation, SUMOylation, poly(ADP-ribosyl)ation, acetylation, redox modification, and glycosylation, in the regulation of plant immunity. The two basic ways by which PTMs communicate as well as the underlying mechanisms and diverse outcomes of the PTM crosstalk in plant immunity are highlighted.



中文翻译:

泛素化与植物免疫中其他翻译后蛋白质修饰之间的串扰

翻译后修饰 (PTM) 是调节蛋白质活性、稳定性、亚细胞定位以及与伴侣相互作用的核心。它们极大地扩展了蛋白质组的多样性和功能,并作为调节众多细胞和生理过程的关键参与者占据了中心位置。越来越多的证据表明,除了单个调节性 PTM 外,许多蛋白质还被多种不同类型的 PTM 以精心策划的方式修饰,以共同调节生物学结果。这种 PTM 串扰会导致细胞中蛋白质组数量的组合爆炸,并大大提高植物对不同外部和内部线索快速建立和微调响应的能力。虽然已经在人类、动物和酵母中深入研究了 PTM 串扰,植物中不同 PTM 之间相互作用的研究仍处于起步阶段。在过去的十年中,研究表明 PTM 广泛参与并在调节植物与病原体之间的相互作用中发挥着关键作用。特别是,泛素化已成为植物免疫的关键调节剂。这篇综述讨论了泛素化和其他六种 PTMs(即磷酸化、SUMOylation、聚(ADP-核糖基)化、乙酰化、氧化还原修饰和糖基化)在植物免疫调节中的串扰的最新研究。重点介绍了 PTM 通信的两种基本方式,以及 PTM 串扰在植物免疫中的潜在机制和不同结果。研究表明,PTM 广泛参与并在调节植物与病原体之间的相互作用中发挥关键作用。特别是,泛素化已成为植物免疫的关键调节剂。这篇综述讨论了泛素化和其他六种 PTMs(即磷酸化、SUMOylation、聚(ADP-核糖基)化、乙酰化、氧化还原修饰和糖基化)在植物免疫调节中的串扰的最新研究。重点介绍了 PTM 通信的两种基本方式,以及 PTM 串扰在植物免疫中的潜在机制和不同结果。研究表明,PTM 广泛参与并在调节植物与病原体之间的相互作用中发挥关键作用。特别是,泛素化已成为植物免疫的关键调节剂。这篇综述讨论了泛素化和其他六种 PTMs(即磷酸化、SUMOylation、聚(ADP-核糖基)化、乙酰化、氧化还原修饰和糖基化)在植物免疫调节中的串扰的最新研究。重点介绍了 PTM 通信的两种基本方式,以及 PTM 串扰在植物免疫中的潜在机制和不同结果。这篇综述讨论了泛素化和其他六种 PTMs(即磷酸化、SUMOylation、聚(ADP-核糖基)化、乙酰化、氧化还原修饰和糖基化)在植物免疫调节中的串扰的最新研究。重点介绍了 PTM 通信的两种基本方式,以及 PTM 串扰在植物免疫中的潜在机制和不同结果。这篇综述讨论了泛素化和其他六种 PTMs(即磷酸化、SUMOylation、聚(ADP-核糖基)化、乙酰化、氧化还原修饰和糖基化)在植物免疫调节中的串扰的最新研究。重点介绍了 PTM 通信的两种基本方式,以及 PTM 串扰在植物免疫中的潜在机制和不同结果。

更新日期:2020-03-25
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