PURPOSE OF REVIEW Different factors contribute to the decreased overall long-term survival in treated people living with HIV (PLWH). This paper will review the state of physical frailty which limits successful aging in PLWH. RECENT FINDINGS Identifiable events on the continuum from clinical normality to heightened risk of adverse health outcomes contribute to frailty. These center on chronic inflammation leading to destabilization of autoregulated physiologic systems challenged by environmental and biologic challenges. Frailty assessment can inform the profile of aging PLWH at increased risk of common age-related disorders and geriatric syndromes. Biologic and psychosocial risk factors promoting progression to and reversion from a dynamic state of frailty are being investigated, allowing for preventative interventions to be considered. Insights gained from studying frail PLWH will help adapt an interdisciplinary geriatric model of health care for selected PLWH. This will improve the health and well-being of aging PLWH.

中文翻译：

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艾滋病毒携带者的脆弱。

审查的目的不同因素导致艾滋病毒感染者（PLWH）的总体长期生存率下降。本文将回顾身体虚弱的状况，该状况限制了PLWH的成功衰老。最新发现从临床正常到不良健康后果风险增加的连续性方面的可识别事件，都导致身体虚弱。这些集中于慢性炎症，其导致受到环境和生物挑战的自动调节的生理系统的不稳定。脆弱性评估可以告知衰老的PLWH在常见的与年龄相关的疾病和老年综合症的风险增加中的概况。正在研究促进向脆弱的动态状态发展和逆转的生物学和社会心理风险因素，可以考虑采取预防性干预措施。通过研究脆弱的PLWH获得的见解将有助于为选定的PLWH改编跨学科的医疗保健老年医学模型。这将改善衰老的PLWH的健康和福祉。