Abstract A kind of red emissive carbon dots (R-CDs) that were synthesized by a hydrothermal method reacted with PEG polymer (mPEG-CHO) as nanocarriers (R-CD@mPEG-CHO). DOX was selected to be the model drug and loaded on the surface of R-CDs by physical adsorption. The mPEG-CHO polymer reacted with R-CDs and the benzoic acid-amine bond was formed through click reaction, which enabled the R-CD@mPEG-CHO to have pH responsive ability in tumor microenvironment and achieved controlled drug release. And PEGylation can suppress drug burst release in vitro. A potential multi-functional nanocarrier system was successfully built.

中文翻译：

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基于多功能碳点的纳米颗粒耦合光学和 pH 依赖性药物释放特性作为药物递送平台

摘要 以聚乙二醇聚合物（mPEG-CHO）为纳米载体（R-CD@mPEG-CHO），采用水热法合成了一种红色发光碳点（R-CDs）。选择 DOX 作为模型药物并通过物理吸附负载在 R-CDs 表面。mPEG-CHO聚合物与R-CDs反应，通过点击反应形成苯甲酸-胺键，使R-CD@mPEG-CHO在肿瘤微环境中具有pH响应能力，实现药物控释。并且聚乙二醇化可以在体外抑制药物突释。成功构建了一个潜在的多功能纳米载体系统。