PURPOSE Kidney cancer survivors spend large quantities of time sedentary and little time physically active, which negatively impacts quality of life (QoL). This study examined (1) the association of reallocating sedentary time to sleep, light physical activity (PA), or moderate-to-vigorous PA (MVPA) on QoL in kidney cancer survivors and (2) the threshold at which results are clinically meaningful. METHODS Kidney cancer survivors (N = 463) completed a survey including the Godin Leisure-Time Exercise Questionnaire, sitting time, sleep duration, and Functional Assessment of Cancer Therapy (FACT) scales. Isotemporal substitution analyses estimated associations of reallocating sedentary time to PA and sleep on QoL. RESULTS Reallocating 10 min/day of sedentary time to MVPA was significantly associated with higher scores on the Trial Outcome Index-Fatigue (B = 0.60, SE = 0.25, p = 0.02), FACT-Fatigue (B = 0.71, SE = 0.32, p = 0.03), functional well-being (B = 0.18, SE = 0.08, p = 0.02), and fatigue subscales (B = 0.35, SE = 0.15, p = 0.02). Reallocating sedentary time to sleep was significantly associated with higher FACT-General (B = 0.15, SE = 0.08, p = 0.04) and functional well-being subscale (B = 0.06, SE = 0.03, p = 0.049) scores. Reallocating sedentary time to light PA was significantly associated with higher fatigue subscale scores (B = 0.46, SE = 0.23, p = 0.045). Kidney cancer survivors would need to reallocate a minimum of about 83, 200, and 65 min/day of MVPA, sleep, and light PA, respectively, for associations to be clinically meaningful. CONCLUSIONS Reallocating sedentary time to MVPA, light PA, or sleep at higher doses is associated with better fatigue and physical aspects of QoL. Interventions should consider replacing sedentary time with MVPA or light PA in a gradual manner, and improve sleep quality for kidney cancer survivors.

中文翻译：

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通过运动和睡眠来代替久坐时间：与肾癌幸存者的生活质量相关。

目的肾癌幸存者花费大量时间久坐，很少运动，这对生活质量（QoL）产生了负面影响。这项研究调查了（1）肾癌幸存者重新分配久坐时间，轻度身体活动（PA）或中度至剧烈PA（MVPA）与QoL的相关性，以及（2）结果具有临床意义的阈值。方法肾脏癌幸存者（N = 463）完成了一项调查，包括《戈丁休闲时间运动问卷》，就座时间，睡眠时间和癌症治疗功能评估（FACT）量表。等时替代分析了将久坐时间重新分配给PA和QoL睡眠的估计关联。结果将久坐时间重新分配给MVPA 10分钟/天与试验结果指数-疲劳（B = 0.60，SE = 0.25，p = 0.02），FACT-疲劳（B = 0.71，SE = 0.32， p = 0.03），功能性健康（B = 0.18，SE = 0.08，p = 0.02）和疲劳分量表（B = 0.35，SE = 0.15，p = 0.02）。重新分配久坐时间与较高的FACT-General（B = 0.15，SE = 0.08，p = 0.04）和功能性幸福感量表（B = 0.06，SE = 0.03，p = 0.049）显着相关。将久坐时间重新分配给轻型PA与较高的疲劳子量表得分显着相关（B = 0.46，SE = 0.23，p = 0.045）。肾脏癌幸存者将需要至少每天分别分配至少约83、200和65分钟的MVPA，睡眠和轻度PA，以使这种关联具有临床意义。结论将久坐时间重新分配给较高剂量的MVPA，轻度PA或睡眠，可改善QoL的疲劳和身体状况。干预措施应考虑逐步用MVPA或轻度PA代替久坐时间，并改善肾癌幸存者的睡眠质量。