Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis,RSC Chemical Biology

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Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis
RSC Chemical Biology ( IF 4.2 ) Pub Date : 2020-03-24 , DOI: 10.1039/c9cb00015a
Joshua C Corpuz ₁ , Larissa M Podust ₂ , Tony D Davis ₁ , Matt J Jaremko ₁ , Michael D Burkart ₁

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Using a covalent chemical probe and X-ray crystallography coupled to nuclear magnetic resonance data, we elucidated the dynamic molecular basis of protein recognition between the carrier protein and adenylation domain in pyoluteorin biosynthesis. These findings reveal a unique binding mode, which contrasts previously solved carrier protein and partner protein interfaces.

中文翻译：

幽门螺杆菌生物合成中II型肽基载体蛋白识别的动态可视化

使用共价化学探针和结合核磁共振数据的 X 射线晶体学，我们阐明了 pyoluteorin 生物合成中载体蛋白和腺苷酸化结构域之间蛋白质识别的动态分子基础。这些发现揭示了一种独特的结合模式，与之前解决的载体蛋白和伙伴蛋白界面形成鲜明对比。

更新日期：2020-03-24

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