BACKGROUND Cardiac damage triggered by severe hypocalcemia is well known. However, the role of chronic hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP) in cardiac health is still unclear. We investigated the effect of chronic HP and PHP on cardiac structure and conductive function in patients compiling with treatment. METHODS The study included 18 patients with HP and eight with PHP aged 45.4 ± 15.4 and 22.1 ± 6.4 years, respectively with a previously regular follow-up. In addition, 26 age- and sex-matched healthy controls were included. General characteristics and biochemical indices were recorded. Cardiac function and structure were assessed by estimation of myocardial enzymes, B-type natriuretic peptide (BNP), and echocardiography. The 12-lead electrocardiogram and 24-h Holter electrocardiography were performed to evaluate the conductive function. RESULTS Levels of serum calcium in HP and PHP were 2.05 ± 0.16 mmol/L and 2.25 ± 0.19 mmol/L, respectively. The levels of myocardial enzyme and BNP were within the normal range. Adjusting for age at evaluation and body mass index, all M-mode measurements, left ventricular mass (LVM), LVM index (LVMI) and relative wall thickness (RWT) were comparable between patients and controls. Prolongation of corrected QT (QTc) intervals occurred in 52.6% (10/19) of patients, and 6.7% (1/15) of patients manifested more than 100 episodes of supraventricular and ventricular extrasystoles, as well as supraventricular tachycardia. None of the above arrhythmias was related to a severe clinical event. CONCLUSIONS From this pilot study, patients diagnosed with HP and PHP and well-controlled serum calcium levels manifested normal cardiac morphology and ventricular function, except for prolonged QTc intervals, and a small percentage of mild arrhythmias needing further investigation.

中文翻译：

---

慢性甲状旁腺功能减退症和假性甲状旁腺功能减退症患者左室功能障碍和心律不齐的表现：一项初步研究。

背景技术由严重的低钙血症引起的心脏损害是众所周知的。但是，慢性甲状旁腺功能低下（HP）和假性甲状旁腺功能低下（PHP）在心脏健康中的作用仍不清楚。我们研究了慢性HP和PHP对接受治疗的患者心脏结构和传导功能的影响。方法该研究包括18例HP患者和8例PHP，年龄分别为45.4±15.4和22.1±6.4岁，分别接受了定期的随访。此外，还包括26个年龄和性别匹配的健康对照。记录一般特征和生化指标。通过评估心肌酶，B型利钠肽（BNP）和超声心动图评估心脏功能和结构。进行12导联心电图和24小时动态心电图检查以评估传导功能。结果HP和PHP中的血清钙水平分别为2.05±0.16 mmol / L和2.25±0.19 mmol / L。心肌酶和BNP水平在正常范围内。在评估年龄和体重指数时，所有M型测量，左心室重量（LVM），LVM指数（LVMI）和相对壁厚（RWT）在患者和对照组之间均具有可比性。校正后的QT（QTc）间隔的延长发生在52.6％（10/19）的患者中，而6.7％（1/15）的患者表现出超过100次的室上性和室性前收缩以及室上性心动过速。上述心律失常均与严重的临床事件无关。结论从这项初步研究中，