N6-methyladenosine (m6A) is the most abundant posttranscriptional modification in mammalian mRNA molecules and has a crucial function in the regulation of many fundamental biological processes. The m6A modification is a dynamic and reversible process regulated by a series of writers, erasers and readers (WERs). Different WERs might have different functions, and even the same WER might function differently in different conditions, which are mostly due to different downstream genes being targeted by the WERs. Therefore, identification of the targets of WERs is particularly important for elucidating this dynamic modification. However, there is still no public repository to host the known targets of WERs. Therefore, we developed the m6A WER target gene database (m6A2Target) to provide a comprehensive resource of the targets of m6A WERs. M6A2Target provides a user-friendly interface to present WER targets in two different modules: 'Validated Targets', referred to as WER targets identified from low-throughput studies, and 'Potential Targets', including WER targets analyzed from high-throughput studies. Compared to other existing m6A-associated databases, m6A2Target is the first specific resource for m6A WER target genes. M6A2Target is freely accessible at http://m6a2target.canceromics.org.

中文翻译：

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M6A2Target：一个针对 m6A 写入器、擦除器和读取器目标的综合数据库。

N6-甲基腺苷 (m6A) 是哺乳动物 mRNA 分子中最丰富的转录后修饰，在许多基本生物过程的调节中具有关键作用。m6A 修改是由一系列写入器、擦除器和读取器 (WER) 调节的动态和可逆过程。不同的WERs可能有不同的功能，甚至同一个WER在不同的条件下也可能有不同的功能，这主要是由于WERs靶向的下游基因不同。因此，识别 WER 的目标对于阐明这种动态修改尤为重要。但是，仍然没有公共存储库来托管 WER 的已知目标。因此，我们开发了 m6A WER 靶基因数据库（m6A2Target），以提供 m6A WER 靶标的综合资源。M6A2Target 提供了一个用户友好的界面，以在两个不同的模块中呈现 WER 目标：“验证目标”，称为从低通量研究中确定的 WER 目标，以及“潜在目标”，包括从高通量研究中分析的 WER 目标。与其他现有的 m6A 相关数据库相比，m6A2Target 是 m6A WER 靶基因的第一个特定资源。M6A2Target 可在 http://m6a2target.canceromics.org 上免费访问。m6A2Target 是 m6A WER 靶基因的第一个特定资源。M6A2Target 可在 http://m6a2target.canceromics.org 上免费访问。m6A2Target 是 m6A WER 靶基因的第一个特定资源。M6A2Target 可在 http://m6a2target.canceromics.org 上免费访问。