Tyrosinase is the rate‐limiting enzyme in melanogenesis. Thiamidol is the most potent inhibitor of human tyrosinase out of 50 000 tested compounds. In clinical studies, it was shown to improve facial hyperpigmentation, post‐inflammatory hyperpigmentation and age spots significantly. To identify the optimal number of daily Thiamidol applications, we conducted a split‐face study comparing the efficacy and tolerability of four‐times with two‐times daily application. Subsequently, we evaluated the efficacy and tolerability of a typical face care regimen containing Thiamidol in a real‐world study.

中文翻译：

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面部色素沉着过度的含硫胺醇治疗方案：一种国际多中心方法，包括双盲、对照、分面研究和开放标签、真实世界研究。

酪氨酸酶是黑色素生成的限速酶。硫胺醇是 50 000 种测试化合物中最有效的人类酪氨酸酶抑制剂。在临床研究中，它被证明可以显着改善面部色素沉着过度、炎症后色素沉着过度和老年斑。为了确定每日硫胺醇应用的最佳次数，我们进行了一项分面研究，比较了每日应用四次与每日两次应用的疗效和耐受性。随后，我们在真实世界的研究中评估了含有硫胺醇的典型面部护理方案的功效和耐受性。